An international multi-clinic study comparing the therapeutic efficacy of colloidal bismuth subcitrate coated tablets with chewing tablets in the treatment of duodenal ulceration.

An international multi-clinic study comparing the therapeutic efficacy of colloidal bismuth subcitrate coated tablets with chewing tablets in the treatment of duodenal ulceration. Research Abstract Details 

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An international multi-clinic study comparing the therapeutic efficacy of colloidal bismuth subcitrate coated tablets with chewing tablets in the treatment of duodenal ulceration. Abstract Text:

W Dekker,P R Dal Monte,G Bianchi Porro,N Van Bentem,J C Boekhorst,J P Crowe,T J Robinson,O Thys,A Van Driel,

The results of a randomized, single-blind, multi-clinic study comparing the therapeutic efficacy and degree of oral staining of new colloidal bismuth subcitrate (CBS) coated tablets over 4 weeks of treatment in patients suffering from duodenal ulceration are reported. The data were collected from 9 clinics in the Netherlands, Belgium, Ireland, the United Kingdom, and Italy. The results from 94 patients treated with CBS coated tablets and 95 patients treated with CBS chewing tablets were statistically evaluated. Healing rates after 4 weeks of therapy appeared to be 76% for CBS coated tablets and 72% for CBS chewing tablets, so no statistically significant difference in therapeutic efficacy was seen. A highly significant degree of discolouration of all parts of the oral cavity was observed in patients treated with CBS chewing tablets, whereas only a few patients treated with CBS coated tablets experienced a slight staining of the tongue. Blood bismuth concentrations during the study had a range of less than or equal to 3 to 33 micrograms/l. The new CBS coated tablet form has an excellent patient compliance as compared to the chewing tablets.

An international multi-clinic study comparing the therapeutic efficacy of colloidal bismuth subcitrate coated tablets with chewing tablets in the treatment of duodenal ulceration. Publishing Authors By Initials

W Dekker,PR Dal Monte,G Bianchi Porro,N Van Bentem,JC Boekhorst,JP Crowe,TJ Robinson,O Thys,A Van Driel,

For similar pharmaceutical preparations: dosage forms: tablets research abstracts see: pharmaceutical preparations: dosage forms: tablets research

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An international multi-clinic study comparing the therapeutic efficacy of colloidal bismuth subcitrate coated tablets with chewing tablets in the treatment of duodenal ulceration. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME: 122

Page Numbers: 46-50

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 1986

An international multi-clinic study comparing the therapeutic efficacy of colloidal bismuth subcitrate coated tablets with chewing tablets in the treatment of duodenal ulceration. Information

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LANGUAGE: eng

NlmUniqueID: 437034

An international multi-clinic study comparing the therapeutic efficacy of colloidal bismuth subcitrate coated tablets with chewing tablets in the treatment of duodenal ulceration. Keywords Mesh Terms:

KEYWORDS: Tablets

MESH TERMS: drug therapy

Chemical & Substance for Abstract: An international multi-clinic study comparing the therapeutic efficacy of colloidal bismuth subcitrate coated tablets with chewing tablets in the treatment of duodenal ulceration. Information

Substance Name: Bismuth

Registry Number: 7440-69-9

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Country: NORWAY

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MEDLINETA: Scand J Gastroenterol Suppl

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