An international approach to the treatment of Hodgkin's disease in the elderly: launch of the SHIELD study programme.

An international approach to the treatment of Hodgkin's disease in the elderly: launch of the SHIELD study programme. Research Abstract Details 

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An international approach to the treatment of Hodgkin's disease in the elderly: launch of the SHIELD study programme. Abstract Text:

Utilising the Scotland and Newcastle Lymphoma Group population data for Hodgkin's disease (HD), collected over a 20-year period, it is evident that 20% of patients are over the age of 60 yr at diagnosis. Data from 674 patients are available. This group comprised 346 men and 328 women. Median follow-up was 9.5 yr. In total 361 patients had stage I/II disease. In this cohort overall response and complete response (CR) rates were 88% and 79%, respectively, for treated patients. Overall 308 patients had stage III/IV disease. Among treated patients in this cohort, overall and CR rates were 78% and 59%, respectively. Response data were missing for 26 patients with stage I/II disease and 43 patients with stage III/IV disease. The chlorambucil, vinblastine, procarbazine and prednisolone, mechlorethamine, vincristine, probarbazine and prednisolone and doxorubicin, bleomycin, vinblastine and decarbazine were the commonest chemotherapy regimens, in descending order of frequency, used to treat this cohort of patients. Outcome did not vary with these regimens. Thirty-four other chemotherapy combinations were used, some curative others palliative. These data and all other published studies confirm the need for a prospective, age-defined approach to HD in the elderly. Such an approach needs to be closely linked to issues of comorbidity, an assessment of frailness and the tailoring of specific protocols for the elderly to allow full dose delivery. The Study of Hodgkin Lymphoma In the Elderly/Lymphoma Database programme has now been launched and attempts to address these issues (http://www.shieldstudy.co.uk).

An international approach to the treatment of Hodgkin's disease in the elderly: launch of the SHIELD study programme. Publishing Authors By Initials

For similar diagnosis: diagnostic techniques and procedures: neoplasm staging research abstracts see: diagnosis: diagnostic techniques and procedures: neoplasm staging research

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An international approach to the treatment of Hodgkin's disease in the elderly: launch of the SHIELD study programme. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of haematology. Supplementum

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Page Numbers: 63-7

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ISSN: 0902-4506

DAY: 26

MONTH: Jul

YEAR: 2005

An international approach to the treatment of Hodgkin's disease in the elderly: launch of the SHIELD study programme. Information

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LANGUAGE: eng

NlmUniqueID: 8703474

An international approach to the treatment of Hodgkin's disease in the elderly: launch of the SHIELD study programme. Keywords Mesh Terms:

KEYWORDS: Neoplasm Staging

MESH TERMS: therapy

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Grant and Affiliation Information for An international approach to the treatment of Hodgkin's disease in the elderly: launch of the SHIELD study programme.

AFFILIATION: Department of Academic Haematology, Medical School, University of Newcastle, Newcastle upon Tyne, UK. s.j.proctor@ncl.ac.uk

Country: Denmark

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MEDLINETA: Eur J Haematol Suppl

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