An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes.

An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes. Research Abstract Details 

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An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes. Abstract Text:

Lei Bao,Jeremy L Peirce,Mi Zhou,Hongqiang Li,Dan Goldowitz,Robert W Williams,Lu Lu,Yan Cui,

Naturally occurring genetic variations may affect certain phenotypes through influencing transcript levels of the genes that are causally related to those phenotypes. Genomic regions harboring common sequence variants that modulate gene expression can be mapped as quantitative trait loci (QTLs) using a newly developed genetical genomics approach. This enables a new strategy for systematically mapping novel genetic loci underlying various phenotypes. In this work, we started from a seed set of genes with variants that are known to affect behavioral and neurological phenotypes (as recorded in Mammalian Phenotype Ontology Database) and used microarrays to analyze their expression levels in brain samples of a panel of BXD recombinant inbred mouse strains. We then systematically mapped the QTLs controlling the expression of these genes. Candidate causal genes in the QTL intervals were evaluated for evidence of functional genetic polymorphisms. Using this method, we were able to predict novel genetic loci and causal genes for a number of behavioral and neurological phenotypes. Lines of independent evidence supporting some of our results were provided by transcription factor binding site analysis and by biomedical literature. This strategy integrates gene-phenotype relations from decades of experimental mutagenesis studies and new genomic resources to provide an approach to rapidly expand knowledge on genetic loci modulating phenotypes.

An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes. Publishing Authors By Initials

L Bao,JL Peirce,M Zhou,H Li,D Goldowitz,RW Williams,L Lu,Y Cui,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research

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An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Human molecular genetics

VOLUME: 16

Page Numbers: 1381-90

Journal Abbreviation: Hum. Mol. Genet.

ISSN: 0964-6906

DAY: 11

MONTH: 04

YEAR: 2007

An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes. Information

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LANGUAGE: eng

NlmUniqueID: 9208958

An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes. Keywords Mesh Terms:

KEYWORDS: RNA, Messenger

MESH TERMS: metabolism

Chemical & Substance for Abstract: An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes.

AFFILIATION: Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Country: England

AGENCY: United States NICHD

GRANT: HD052472

ACRONYM: HD

MEDLINETA: Hum Mol Genet

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