An integrative approach to understanding mechanosensation.

An integrative approach to understanding mechanosensation. Research Abstract Details 

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An integrative approach to understanding mechanosensation. Abstract Text:

Christopher C Poirier,Pablo A Iglesias,

The ability for a living organism to sense and respond to its external environment is crucial to its survival. Understanding mechanosensation, the mechanism by which organisms react in response to mechanical stimuli, presents many interesting and challenging problems for both experimental and computational biologists. A major difficulty in studying mechanosensors is their inherent multiscale nature. The systems involved in mechanosesnsing can span eight orders of magnitude in length scale and up to 10 orders of magnitude in time scale. Trying to ascertain information across these length and time scales simultaneously is challenging. This problem has led to the need to approach these types of problems using an integrative approach, combining both computational and experimental biology. This review classifies the major types of mechanosensors and explains methods that have been employed in understanding their behavior, both using modeling and experimental techniques. Multiscale modeling methods combined with experimental techniques in an integrative approach are suggested as ways of undertaking the study of such systems.

An integrative approach to understanding mechanosensation. Publishing Authors By Initials

CC Poirier,PA Iglesias,

For similar natural sciences: science: systems integration research abstracts see: natural sciences: science: systems integration research

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MEDLINE DATE:

An integrative approach to understanding mechanosensation. Journal Published:

PUBLICATION TYPE: Review

Journal: Briefings in bioinformatics

VOLUME: 8

Page Numbers: 258-65

Journal Abbreviation: Brief. Bioinformatics

ISSN: 1467-5463

DAY: 25

MONTH: 06

YEAR: 2007

An integrative approach to understanding mechanosensation. Information

Number of References: 66

LANGUAGE: eng

NlmUniqueID: 100912837

An integrative approach to understanding mechanosensation. Keywords Mesh Terms:

KEYWORDS: Systems Integration

MESH TERMS: physiology

Chemical & Substance for Abstract: An integrative approach to understanding mechanosensation. Information

Substance Name: Ion Channels

Registry Number: 0

Grant and Affiliation Information for An integrative approach to understanding mechanosensation.

AFFILIATION: Department of Electrical & Computer Engineering, The Johns Hopkins University, 3400North Charles Street, Baltimore, MD 21218, USA.

Country: England

AGENCY: United States PHS

GRANT: 72024

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MEDLINETA: Brief Bioinform

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