An integrated glucose-insulin model to describe oral glucose tolerance test data in type 2 diabetics.

An integrated glucose-insulin model to describe oral glucose tolerance test data in type 2 diabetics. Research Abstract Details 

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An integrated glucose-insulin model to describe oral glucose tolerance test data in type 2 diabetics. Abstract Text:

Petra M Jauslin,Hanna E Silber,Nicolas Frey,Ronald Gieschke,Ulrika S H Simonsson,Karin Jorga,Mats O Karlsson,Petra M Jauslin,Hanna E Silber,Nicolas Frey,Ronald Gieschke,Ulrika S H Simonsson,Karin Jorga,Mats O Karlsson,

An integrated model for the glucose-insulin system describing oral glucose tolerance test data was developed, extending on a previously introduced model for intravenous glucose provocations. Model extensions comprised the description of glucose absorption by a chain of transit compartments with a mean transit time of 35 minutes, a bioavailability of 80%, and a representation of the incretin effect, expressed as a direct effect of the glucose absorption rate on insulin secretion. The ability of the model to predict the incretin effect was assessed by simulating the observed difference in insulin response following an oral glucose tolerance test compared with an isoglycemic glucose infusion mimicking an oral glucose tolerance test profile. The extension of the integrated glucose-insulin model to gain information from oral glucose tolerance test data considerably expands its range of applications because the oral glucose tolerance test is one of the most common glucose challenge experiments for assessing the efficacy of hypoglycemic agents in clinical drug development.

An integrated glucose-insulin model to describe oral glucose tolerance test data in type 2 diabetics. Publishing Authors By Initials

PM Jauslin,HE Silber,N Frey,R Gieschke,US Simonsson,K Jorga,MO Karlsson,PM Jauslin,HE Silber,N Frey,R Gieschke,US Simonsson,K Jorga,MO Karlsson,

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An integrated glucose-insulin model to describe oral glucose tolerance test data in type 2 diabetics. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of clinical pharmacology

VOLUME: 47

Page Numbers: 1244-55

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ISSN: 0091-2700

DAY: 1

MONTH: Oct

YEAR: 2007

An integrated glucose-insulin model to describe oral glucose tolerance test data in type 2 diabetics. Information

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LANGUAGE: eng

NlmUniqueID: 366372

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Grant and Affiliation Information for An integrated glucose-insulin model to describe oral glucose tolerance test data in type 2 diabetics.

AFFILIATION: Department of Pharmaceutical Biosciences, Division of Pharmacokinetics and Drug Therapy, University of Uppsala, Friggs Grand 4, Halmstad, Sweden.

Country: United States

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MEDLINETA: J Clin Pharmacol

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