An indirect evaluation of the effect of the autonomic nervous system following converting enzyme inhibition in hypertension.

An indirect evaluation of the effect of the autonomic nervous system following converting enzyme inhibition in hypertension. Research Abstract Details 

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An indirect evaluation of the effect of the autonomic nervous system following converting enzyme inhibition in hypertension. Abstract Text:

R G Asmar,A Benetos,B Darne,S Laurent,M E Safar,

Common carotid blood flow and cold pressor test were evaluated in 16 patients with sustained essential hypertension before and after 30 days treatment with the converting enzyme inhibitor Enalapril (20 mg). Enalapril decreased blood pressure and carotid vascular resistance with no significant change in heart rate. After treatment, despite a wide range of the responses, the changes in systolic blood pressure to cold test were significantly attenuated, whereas the heart rate responses were not. Acute random and double blind administration of either Cadralazine or Nitrendipine, two vasodilating drugs which are known to cause an activation of the autonomic nervous system, were performed before and after long term treatment by Enalapril. Whereas the blood pressure and heart rate responses to cold test was unmodified by these compounds before Enalapril treatment, significant changes were observed after converting enzyme inhibition: Cadralazine reduced the heart rate response whereas Nitrendipine increased it significantly. The study provides evidence that converting enzyme inhibition causes sympatho-inhibitory influences which are principally observed in stress conditions, with heterogeneous responses depending on the nature and the type of stimulation.

An indirect evaluation of the effect of the autonomic nervous system following converting enzyme inhibition in hypertension. Publishing Authors By Initials

RG Asmar,A Benetos,B Darne,S Laurent,ME Safar,

For similar chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasodilator agents research abstracts see: chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasodilator agents research

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An indirect evaluation of the effect of the autonomic nervous system following converting enzyme inhibition in hypertension. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 14

Page Numbers: 853-73

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1992

An indirect evaluation of the effect of the autonomic nervous system following converting enzyme inhibition in hypertension. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8207790

An indirect evaluation of the effect of the autonomic nervous system following converting enzyme inhibition in hypertension. Keywords Mesh Terms:

KEYWORDS: Vasodilator Agents

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: An indirect evaluation of the effect of the autonomic nervous system following converting enzyme inhibition in hypertension. Information

Substance Name: Enalapril

Registry Number: 75847-73-3

Grant and Affiliation Information for An indirect evaluation of the effect of the autonomic nervous system following converting enzyme inhibition in hypertension.

AFFILIATION: Department of Internal Medicine, Broussais Hospital, Paris, France.

Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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