An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus.

An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Research Abstract Details 

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An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Abstract Text:

Ana C Pereira,Dan E Huddleston,Adam M Brickman,Alexander A Sosunov,Rene Hen,Guy M McKhann,Richard Sloan,Fred H Gage,Truman R Brown,Scott A Small,

With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate of neurogenesis has become an important goal. Here we rely on the coupling between neurogenesis and angiogenesis and test whether MRI measurements of cerebral blood volume (CBV) provide an imaging correlate of neurogenesis. First, we used an MRI approach to generate CBV maps over time in the hippocampal formation of exercising mice. Among all hippocampal subregions, exercise was found to have a primary effect on dentate gyrus CBV, the only subregion that supports adult neurogenesis. Moreover, exercise-induced increases in dentate gyrus CBV were found to correlate with postmortem measurements of neurogenesis. Second, using similar MRI technologies, we generated CBV maps over time in the hippocampal formation of exercising humans. As in mice, exercise was found to have a primary effect on dentate gyrus CBV, and the CBV changes were found to selectively correlate with cardiopulmonary and cognitive function. Taken together, these findings show that dentate gyrus CBV provides an imaging correlate of exercise-induced neurogenesis and that exercise differentially targets the dentate gyrus, a hippocampal subregion important for memory and implicated in cognitive aging.

An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Publishing Authors By Initials

AC Pereira,DE Huddleston,AM Brickman,AA Sosunov,R Hen,GM McKhann,R Sloan,FH Gage,TR Brown,SA Small,

For similar nervous system: neurons research abstracts see: nervous system: neurons research

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An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 5638-43

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 20

MONTH: 03

YEAR: 2007

An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Keywords Mesh Terms:

KEYWORDS: Neurons

MESH TERMS: metabolism

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Grant and Affiliation Information for An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus.

AFFILIATION: The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

Country: United States

AGENCY: United States NIA

GRANT: AG025161

ACRONYM: AG

MEDLINETA: Proc Natl Acad Sci U S A

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