An immunohistological study of anhydrous topical ascorbic acid compositions on ex vivo human skin.

An immunohistological study of anhydrous topical ascorbic acid compositions on ex vivo human skin. Research Abstract Details 

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An immunohistological study of anhydrous topical ascorbic acid compositions on ex vivo human skin. Abstract Text:

Geoffrey K Heber,Boban Markovic,Amanda Hayes,

Background Ascorbic acid has numerous essential and beneficial functions in normal and photoaged skin. Ionisation of ascorbic acid in aqueous topical formulations leads to oxidative degradation. Ascorbic acid in an anhydrous vehicle would inherently have greater stability. Objective The objective of this study was to observe the effects of two anhydrous formulations containing microfine particles of ascorbic acid on neocollagenesis and cytokeratin production in ex vivo human skin. Methods Vitamin C preparations were applied topically onto the surface of freshly excised human abdominal skin. Following an exposure time of 48 h with appropriate controls, skin discs were cut into sections, placed on slides and assessed using immunohistochemical (antibodies: collagen type I, III, cytokeratin) staining. Analysis was performed using microscopy and descriptive rating. Results Both formulations resulted in increased production of collagen types I and III and cytokeratin. Conclusion The application of anhydrous formulations containing microfine particles of ascorbic acid to ex vivo human skin in this study resulted in neocollagenesis and increased production of cytokeratin. This approach appears to enable biological effects of ascorbic acid in the skin using a vehicle which would provide it greater stability than an aqueous vehicle.

An immunohistological study of anhydrous topical ascorbic acid compositions on ex vivo human skin. Publishing Authors By Initials

GK Heber,B Markovic,A Hayes,

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An immunohistological study of anhydrous topical ascorbic acid compositions on ex vivo human skin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cosmetic dermatology

VOLUME: 5

Page Numbers: 150-6

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ISSN: 1473-2165

DAY: 18

MONTH: Jun

YEAR: 2006

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LANGUAGE: eng

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Country: England

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MEDLINETA: J Cosmet Dermatol

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