An illustrated review of early pancreas development in the mouse.

An illustrated review of early pancreas development in the mouse. Research Abstract Details 

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An illustrated review of early pancreas development in the mouse. Abstract Text:

Mette Christine ,Jonas ,Jacob Hald,Ole D Madsen,Palle Serup,Jacob ,Mette Christine ,Jonas ,Jacob Hald,Ole D Madsen,Palle Serup,Jacob ,

Pancreas morphogenesis and cell differentiation are highly conserved among vertebrates during fetal development. The pancreas develops through simple budlike structures on the primitive gut tube to a highly branched organ containing many specialized cell types. This review presents an overview of key molecular components and important signaling sources illustrated by an extensive three-dimensional (3D) imaging of the developing mouse pancreas at single cell resolution. The 3D documentation covers the time window between embryonic days 8.5 and 14.5 in which all the pancreatic cell types become specified and therefore includes gene expression patterns of pancreatic endocrine hormones, exocrine gene products, and essential transcription factors. The 3D perspective provides valuable insight into how a complex organ like the pancreas is formed and a perception of ventral and dorsal pancreatic growth that is otherwise difficult to uncover. We further discuss how this global analysis of the developing pancreas confirms and extends previous studies, and we envisage that this type of analysis can be instrumental for evaluating mutant phenotypes in the future.

An illustrated review of early pancreas development in the mouse. Publishing Authors By Initials

MC ,J ,J Hald,OD Madsen,P Serup,J ,MC ,J ,J Hald,OD Madsen,P Serup,J ,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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An illustrated review of early pancreas development in the mouse. Journal Published:

PUBLICATION TYPE: Review

Journal: Endocrine reviews

VOLUME: 28

Page Numbers: 685-705

Journal Abbreviation: Endocr. Rev.

ISSN: 0163-769X

DAY: 19

MONTH: 09

YEAR: 2007

An illustrated review of early pancreas development in the mouse. Information

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LANGUAGE: eng

NlmUniqueID: 8006258

An illustrated review of early pancreas development in the mouse. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

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Substance Name: Transcription Factors

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Grant and Affiliation Information for An illustrated review of early pancreas development in the mouse.

AFFILIATION: Hagedorn Research Institute, Department of Developmental Biology, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark. mecj@hagedorn.dk

Country: United States

AGENCY: United States NIDDK

GRANT: DK072495

ACRONYM: DK

MEDLINETA: Endocr Rev

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