An extranodal NK/T cell lymphoma, nasal type, with specific immunophenotypic and genotypic features.

An extranodal NK/T cell lymphoma, nasal type, with specific immunophenotypic and genotypic features. Research Abstract Details 

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An extranodal NK/T cell lymphoma, nasal type, with specific immunophenotypic and genotypic features. Abstract Text:

Extranodal NK/T cell lymphoma, 'nasal type,' is a rare clinicopathological entity in Europe. The main clinical features are nasal congestion, sore throat, dysphagia and epistaxis, due to a destructive mass involving the midline facial tissues. Pathologically, lymphoma cells exhibit angioinvasion, angiodestruction and coagulative necrosis. We report the case of a patient who presented with fever, dyspnea, nasal congestion, headache, distention of right nasal turbinates and exophytic lower leg ulcerating lesions. A CT scan of visceral scull demonstrated a filling mass of right frontal, ethmoidal and maxillary sinuses with erosion of the wall of right maxillary sinus and ventral portion of the diaphragm. A biopsy was performed in the skin lesion and showed an angioinvasive NK/T cell lymphoma CD56 negative with clonal rearrangement of the T-cell-receptor gamma gene. Up to our knowledge, this is a rare immunophenotype for NK/T-cell, 'nasal type,' lymphomas. However, the lymphoma may be classified as extranodal NK/T cell lymphoma, 'nasal type,' due to typical clinical presentation, radiologic findings and pathological characteristics of polymorphism, angioinvasion, angiodestruction and coagulative necrosis.

An extranodal NK/T cell lymphoma, nasal type, with specific immunophenotypic and genotypic features. Publishing Authors By Initials

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An extranodal NK/T cell lymphoma, nasal type, with specific immunophenotypic and genotypic features. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of hematology

VOLUME: 88

Page Numbers: 202-5

Journal Abbreviation: Int. J. Hematol.

ISSN: 0925-5710

DAY: 25

MONTH: 07

YEAR: 2008

An extranodal NK/T cell lymphoma, nasal type, with specific immunophenotypic and genotypic features. Information

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LANGUAGE: eng

NlmUniqueID: 9111627

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Grant and Affiliation Information for An extranodal NK/T cell lymphoma, nasal type, with specific immunophenotypic and genotypic features.

AFFILIATION: 2nd Department of Medicine, University of Athens Medical School, Hippokration General Hospital, Athens, Greece.

Country: United States

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MEDLINETA: Int J Hematol

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