[An experimental study of the effect of IL-2 on the growth of irradiated intestinal epithelial cells]

[An experimental study of the effect of IL-2 on the growth of irradiated intestinal epithelial cells] Research Abstract Details 

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[An experimental study of the effect of IL-2 on the growth of irradiated intestinal epithelial cells] Abstract Text:

Kai-fei Fu,Rui-yun Peng,Ya-bing Gao,De-wen Wang,Qing-liang Luo,Yi Yang,Bo Dong,

AIM: To observe the effect of ionizing radiation on intestinal epithelial cells 6 (IEC-6) and the effect of IL-2 on the proliferation and recovery of radiation-injured IEC-6 cells. METHODS: IEC-6 cells exposed to 4, 8 and 12 Gy gamma ray were analyzed with MTT colorimetry, light microscopy, electron microscopy, DNA gel electrophoresis and flow cytometry at 3, 6, 9, 12 hours and 1, 2, 3 days after radiation. Proliferation of 8 Gy gamma ray-irradiated IEC-6 cells which was treated with IL-2 was detected by MTT colorimetry at 3, 6, 9, 12 and 24 hours after irradiation. RESULTS: Proliferation of IEC-6 decreased with the increased dose of gamma ray radiation. Apoptotic IEC-6 cells increased apparently at 24 hours after radiation with 8.0 Gy gamma ray, IL-2 could enhance the proliferation of irradiated IEC-6 cells (especially at concentration of 1 x 10(5) U/L) in a dose-dependent manner. CONCLUSION: 4-12 Gy of gamma ray radiation can reduce the proliferation and cause apoptosis of IEC-6 cells. IL-2 can accelerate proliferation of irradiated IEC-6 cells and protect IECs from ionization radiation injury.

[An experimental study of the effect of IL-2 on the growth of irradiated intestinal epithelial cells] Publishing Authors By Initials

KF Fu,RY Peng,YB Gao,DW Wang,QL Luo,Y Yang,B Dong,

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[An experimental study of the effect of IL-2 on the growth of irradiated intestinal epithelial cells] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese jour

VOLUME: 21

Page Numbers: 250-3

Journal Abbreviation: Xi Bao Yu Fen Zi Mian Yi Xue Z

ISSN: 1007-8738

DAY: 15

MONTH: Mar

YEAR: 2005

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LANGUAGE: chi

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AFFILIATION: Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China.

Country: China

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MEDLINETA: Xi Bao Yu Fen Zi Mian Yi Xue Z

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