An evaluation of the change in electrocardiographic P-wave variables after acute caffeine ingestion in normal volunteers.

An evaluation of the change in electrocardiographic P-wave variables after acute caffeine ingestion in normal volunteers. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

An evaluation of the change in electrocardiographic P-wave variables after acute caffeine ingestion in normal volunteers. Abstract Text:

BACKGROUND: Caffeine's effect on supraventricular dysrhythmias is poorly understood, and establishing a marker to predict atrial fibrillation may help to explain supraventricular dysrhythmias caused by caffeine. OBJECTIVE: To evaluate the effects of caffeine (mean 6.1 mg/kg) on maximum P-wave duration and P-wave dispersion in normal volunteers. METHOD: A randomised, double-blind, placebo-controlled, crossover study in 10 healthy volunteers at least 17 years of age at the University of Connecticut. Participants abstained from caffeinated products for at least 2 days before study initiation and were randomly allocated on different days to receive placebo or caffeine 400 mg. For each of the study phases, a baseline 12-lead electrocardiogram (ECG) was performed and a subsequent 12-lead ECG was performed 3 h after ingesting the study drug. RESULTS: No significant changes were found within intra- or intergroup comparisons for any P-wave variables measured. CONCLUSION: Single dose caffeine (400 mg) does not affect average P-wave duration, maximum P-wave duration or P-wave dispersion in normal individuals.

An evaluation of the change in electrocardiographic P-wave variables after acute caffeine ingestion in normal volunteers. Publishing Authors By Initials

For similar pharmaceutical preparations: placebos research abstracts see: pharmaceutical preparations: placebos research

PUBMED ID PMID:

MEDLINE DATE:

An evaluation of the change in electrocardiographic P-wave variables after acute caffeine ingestion in normal volunteers. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 26

Page Numbers: 145-8

Journal Abbreviation: J Clin Pharm Ther

ISSN: 0269-4727

DAY: 28

MONTH: Apr

YEAR: 2001

An evaluation of the change in electrocardiographic P-wave variables after acute caffeine ingestion in normal volunteers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8704308

An evaluation of the change in electrocardiographic P-wave variables after acute caffeine ingestion in normal volunteers. Keywords Mesh Terms:

KEYWORDS: Placebos

MESH TERMS: pharmacology

Chemical & Substance for Abstract: An evaluation of the change in electrocardiographic P-wave variables after acute caffeine ingestion in normal volunteers. Information

Substance Name: Caffeine

Registry Number: 58-08-2

Grant and Affiliation Information for An evaluation of the change in electrocardiographic P-wave variables after acute caffeine ingestion in normal volunteers.

AFFILIATION: University of Connecticut School of Pharmacy, Storrs and Farmington, CT, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Clin Pharm Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

An evaluation of the change in electrocardiographic P-wave variables after acute caffeine ingestion in normal volunteers Related Publications

• A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility.
• A voltage-sensor water pore.
• Chronic vague abdominal pain in children.
• Cimetidine use and the risk for prostate cancer: results from the VITAL cohort study.
• Do breast cancer risk factors modify the association between hormone therapy and mammographic breast density? (United States).
• Effects of photoperiod and intermittent lighting on reproduction in pheasant hens.
• Exposure to the metabolic inhibitor sodium azide induces stress protein expression and thermotolerance in the nematode Caenorhabditis elegans.
• Extremity trauma research in the United States army.
• Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes.
• Harnessing RNAi for Analyses of Ras Signaling and Transformation.
• In vitro maturation and fertilization of swamp buffalo oocytes and their subsequent development.
• Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen.
• Inhibitory control in children with phenylketonuria.
• Kinetic mechanism of myosinV-S1 using a new fluorescent ATP analogue.
• Mammographic breast density, dense area, and breast area differences by phase in the menstrual cycle.
• PGI2 opens potassium channels in retinal pericytes by cyclic AMP-stimulated, cross-activation of PKG.
• Parachutes and prophylaxis: they both work!
• Polyol synthesis through hydrocarbon oxidation: de novo synthesis of L-galactose.
• Post-thawing survival of motile ram sperm after isolation by layering on protein columns.
• Prevalence of Borrelia burgdorferi in small mammals in New York state.
• Prospects for sexing mammalian sperm edited by Rupert P. Amman and George E. Seidel, Jr.; 288 pages; Cloth - $32.50, Paper - $22.50. Available from Colorado Associated University Press, 1338 Grandview Avenue, Box 480, University of Colorado, Boulder, Colo
• Ras-Sensitive IMP Modulation of the Raf/MEK/ERK Cascade Through KSR1.
• Relationship between estrone sulfate in plasma and litter size at farrowing for sows and gilts.
• Spontaneous baroreflex sensitivity in young and older people during voluntary and electrically evoked isometric exercise.
• Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation.
• The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease.
• The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria.
• The preference of tryptophan for membrane interfaces.
• The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling.
• Using verbal fluency to detect very mild dementia of the Alzheimer type.