An essential switch in subunit composition of a chromatin remodeling complex during neural development.

An essential switch in subunit composition of a chromatin remodeling complex during neural development. Research Abstract Details 

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An essential switch in subunit composition of a chromatin remodeling complex during neural development. Abstract Text:

Mammalian neural stem cells (NSCs) have the capacity to both self-renew and to generate all the neuronal and glial cell-types of the adult nervous system. Global chromatin changes accompany the transition from proliferating NSCs to committed neuronal lineages, but the mechanisms involved have been unclear. Using a proteomics approach, we show that a switch in subunit composition of neural, ATP-dependent SWI/SNF-like chromatin remodeling complexes accompanies this developmental transition. Proliferating neural stem and progenitor cells express complexes in which BAF45a, a Krüppel/PHD domain protein and the actin-related protein BAF53a are quantitatively associated with the SWI2/SNF2-like ATPases, Brg and Brm. As neural progenitors exit the cell cycle, these subunits are replaced by the homologous BAF45b, BAF45c, and BAF53b. BAF45a/53a subunits are necessary and sufficient for neural progenitor proliferation. Preventing the subunit switch impairs neuronal differentiation, indicating that this molecular event is essential for the transition from neural stem/progenitors to postmitotic neurons. More broadly, these studies suggest that SWI/SNF-like complexes in vertebrates achieve biological specificity by combinatorial assembly of their subunits.

An essential switch in subunit composition of a chromatin remodeling complex during neural development. Publishing Authors By Initials

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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An essential switch in subunit composition of a chromatin remodeling complex during neural development. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuron

VOLUME: 55

Page Numbers: 201-15

Journal Abbreviation: Neuron

ISSN: 0896-6273

DAY: 19

MONTH: Jul

YEAR: 2007

An essential switch in subunit composition of a chromatin remodeling complex during neural development. Information

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LANGUAGE: eng

NlmUniqueID: 8809320

An essential switch in subunit composition of a chromatin remodeling complex during neural development. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: An essential switch in subunit composition of a chromatin remodeling complex during neural development. Information

Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for An essential switch in subunit composition of a chromatin remodeling complex during neural development.

AFFILIATION: Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS046789

ACRONYM: NS

MEDLINETA: Neuron

REFSOURCE: Neuron. 2007 Jul 19;55(2):171-3

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