An epidermotropic canine papillomavirus with malignant potential contains an E5 gene and establishes a unique genus.

An epidermotropic canine papillomavirus with malignant potential contains an E5 gene and establishes a unique genus. Research Abstract Details 

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An epidermotropic canine papillomavirus with malignant potential contains an E5 gene and establishes a unique genus. Abstract Text:

Hang Yuan,Shinje Ghim,Joe Newsome,Tania Apolinario,Vanessa Olcese,Mary Martin,Hajo Delius,Peter Felsburg,Bennett Jenson,Richard Schlegel,

A novel canine papillomavirus, CfPV-2, was cloned from a footpad lesion of a golden retriever. Unlike the known canine oral papillomavirus (COPV), which has a double-stranded DNA genome size of 8607 bps, the genome of CfPV-2 is 8101 bps. Some of this size difference is due to an abbreviated early-late region (ELR), which is 1200 bps shorter than that of COPV. However, CfPV-2 has other differences from COPV, including the presence of an E5 ORF between the E2 gene and the ELR and an enlarged E4 ORF (one of the largest PV E4 open reading frames). The genome of CfPV-2 shares low homology with all the other papillomaviruses and, even in the most highly conserved ORF of L1, the nucleotide sequence shares only 57% homology with COPV. Due to this highly divergent DNA sequence, CfPV-2 establishes a new PV genus, with its closest phylogenetic relatives being amongst the Xi and Gamma genuses. CfPV-2 also has unique biological features; it induces papillomas on footpads and interdigital regions which, if infection is persistent, can progress to highly metastatic squamous cell carcinoma. CfPV-2 does not induce oral papillomas in immunocompetent animals and antibodies generated against COPV and CfPV-2 are type-specific. The availability of a new canine papillomavirus with differing genetic and biological properties now makes it possible to study type-specific host immune responses, tissue tropism and the comparative analysis of viral gene functions in the dog.

An epidermotropic canine papillomavirus with malignant potential contains an E5 gene and establishes a unique genus. Publishing Authors By Initials

H Yuan,S Ghim,J Newsome,T Apolinario,V Olcese,M Martin,H Delius,P Felsburg,B Jenson,R Schlegel,

For similar viruses: virion research abstracts see: viruses: virion research

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An epidermotropic canine papillomavirus with malignant potential contains an E5 gene and establishes a unique genus. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Virology

VOLUME: 359

Page Numbers: 28-36

Journal Abbreviation: Virology

ISSN: 0042-6822

DAY: 10

MONTH: 10

YEAR: 2006

An epidermotropic canine papillomavirus with malignant potential contains an E5 gene and establishes a unique genus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 110674

An epidermotropic canine papillomavirus with malignant potential contains an E5 gene and establishes a unique genus. Keywords Mesh Terms:

KEYWORDS: Virion

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: An epidermotropic canine papillomavirus with malignant potential contains an E5 gene and establishes a unique genus. Information

Substance Name: DNA, Viral

Registry Number: 0

Grant and Affiliation Information for An epidermotropic canine papillomavirus with malignant potential contains an E5 gene and establishes a unique genus.

AFFILIATION: Department of Pathology, Georgetown University Medical School, 3900 Reservoir Road, NW, Washington, DC 20007, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01CA53371

ACRONYM: CA

MEDLINETA: Virology

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