An enhanced MITOMAP with a global mtDNA mutational phylogeny.

An enhanced MITOMAP with a global mtDNA mutational phylogeny. Research Abstract Details 

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An enhanced MITOMAP with a global mtDNA mutational phylogeny. Abstract Text:

Eduardo Ruiz-Pesini,Marie T Lott,Vincent Procaccio,Jason C Poole,Marty C Brandon,Dan Mishmar,Christina Yi,James Kreuziger,Pierre Baldi,Douglas C Wallace,

The MITOMAP (http://www.mitomap.org) data system for the human mitochondrial genome has been greatly enhanced by the addition of a navigable mutational mitochondrial DNA (mtDNA) phylogenetic tree of approximately 3000 mtDNA coding region sequences plus expanded pathogenic mutation tables and a nuclear-mtDNA pseudogene (NUMT) data base. The phylogeny reconstructs the entire mutational history of the human mtDNA, thus defining the mtDNA haplogroups and differentiating ancient from recent mtDNA mutations. Pathogenic mutations are classified by both genotype and phenotype, and the NUMT sequences permits detection of spurious inclusion of pseudogene variants during mutation analysis. These additions position MITOMAP for the implementation of our automated mtDNA sequence analysis system, Mitomaster.

An enhanced MITOMAP with a global mtDNA mutational phylogeny. Publishing Authors By Initials

E Ruiz-Pesini,MT Lott,V Procaccio,JC Poole,MC Brandon,D Mishmar,C Yi,J Kreuziger,P Baldi,DC Wallace,

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An enhanced MITOMAP with a global mtDNA mutational phylogeny. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Nucleic acids research

VOLUME: 35

Page Numbers: D823-8

Journal Abbreviation: Nucleic Acids Res.

ISSN: 1362-4962

DAY: 18

MONTH: 12

YEAR: 2006

An enhanced MITOMAP with a global mtDNA mutational phylogeny. Information

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LANGUAGE: eng

NlmUniqueID: 411011

An enhanced MITOMAP with a global mtDNA mutational phylogeny. Keywords Mesh Terms:

KEYWORDS: User-Computer Interface

MESH TERMS: genetics

Chemical & Substance for Abstract: An enhanced MITOMAP with a global mtDNA mutational phylogeny. Information

Substance Name: DNA, Mitochondrial

Registry Number: 0

Grant and Affiliation Information for An enhanced MITOMAP with a global mtDNA mutational phylogeny.

AFFILIATION: Center for Molecular and Mitochondrial Medicine and Genetics (MAMMAG) and Departments of Biological Chemistry, Ecology and Evolutionary Biology, and Pediatrics, University of California, Irvine, CA 92697-3900, USA.

Country: England

AGENCY: United States NLM

GRANT: T15 LM007443

ACRONYM: LM

MEDLINETA: Nucleic Acids Res

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