An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer.

An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer. Research Abstract Details 

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An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer. Abstract Text:

G A Rabinovich,F-T Liu,M Hirashima,A Anderson,

Inflammation is a critical process for eliminating pathogens, but can lead to serious deleterious effects if left unchecked. Identifying the endogenous factors that control immune tolerance and inflammation is a key goal in the field of immunology. Galectins, a family of endogenous lectins with affinity for beta-galactoside-containing oligosaccharides, are expressed by several cells of the immune system and tissue-resident stromal cells. According to their architecture, this family of glycan-binding proteins is classified in those containing one-carbohydrate-recognition domain (CRD) (proto-type), those containing two-CRD joined by a linker non-lectin domain (tandem-repeat) and those that have one-CRD attached to an N-terminal peptide (chimera-type). Accumulating evidence indicates that galectins play critical regulatory roles in immune cell response and homeostasis. In this review, we summarize recent developments in our understanding of the galectins' roles within different immune cell compartments, and in the broader context of the inflammatory microenvironments. In particular we illustrate the immunoregulatory role of three representative members of each galectin subfamily: galectin-1, -3 and -9. This body of knowledge, documenting the coming of age of galectins as potential immunosuppressive agents or targets for anti-inflammatory drugs, represents a sound basis to further explore their potential as novel therapies for autoimmune diseases, chronic inflammation and cancer.

An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer. Publishing Authors By Initials

GA Rabinovich,FT Liu,M Hirashima,A Anderson,

For similar neoplasms: neoplasms, experimental research abstracts see: neoplasms: neoplasms, experimental research

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An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer. Journal Published:

PUBLICATION TYPE: Review

Journal: Scandinavian journal of immunology

VOLUME: 66

Page Numbers: 143-58

Journal Abbreviation: Scand. J. Immunol.

ISSN: 0300-9475

DAY: 3

MONTH: 12

YEAR: 2007

An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer. Information

Number of References: 143

LANGUAGE: eng

NlmUniqueID: 323767

An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer. Keywords Mesh Terms:

KEYWORDS: Neoplasms, Experimental

MESH TERMS: metabolism

Chemical & Substance for Abstract: An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer. Information

Substance Name: Inflammation Mediators

Registry Number: 0

Grant and Affiliation Information for An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer.

AFFILIATION: Department of Immunopathology, Institute of Biology and Experimental Medicine (IBYME/ CONICET), Buenos Aires, Argentina. gabyrabi@ciudad.com.ar

Country: England

AGENCY: United States NIAID

GRANT: R01 AI39620

ACRONYM: AI

MEDLINETA: Scand J Immunol

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