An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function.

An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function. Research Abstract Details 

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An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function. Abstract Text:

T S Vivian Liao,Gerald B Call,Preeta Guptan,Albert Cespedes,Jamie Marshall,Kevin Yackle,Edward Owusu-Ansah,Sudip Mandal,Q Angela Fang,Gelsey L Goodstein,William Kim,Utpal Banerjee,

We conducted a screen for glossy-eye flies that fail to incorporate BrdU in the third larval instar eye disc but exhibit normal neuronal differentiation and isolated 23 complementation groups of mutants. These same phenotypes were previously seen in mutants for cytochrome c oxidase subunit Va. We have molecularly characterized six complementation groups and, surprisingly, each encodes a mitochondrial protein. Therefore, we believe our screen to be an efficient method for identifying genes with mitochondrial function.

An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function. Publishing Authors By Initials

TS Liao,GB Call,P Guptan,A Cespedes,J Marshall,K Yackle,E Owusu-Ansah,S Mandal,QA Fang,GL Goodstein,W Kim,U Banerjee,

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An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genetics

VOLUME: 174

Page Numbers: 525-33

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ISSN: 0016-6731

DAY: 18

MONTH: 07

YEAR: 2006

An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function. Information

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LANGUAGE: eng

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AFFILIATION: Molecular Biology Institute, University of California, Los Angeles, California 90095, USA.

Country: United States

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MEDLINETA: Genetics

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