An efficient family-based association test using multiple markers.

An efficient family-based association test using multiple markers. Research Abstract Details 

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An efficient family-based association test using multiple markers. Abstract Text:

Xin Xu,Cyril Rakovski,Xiping Xu,Nan Laird,

In genetic association studies, multiple markers are usually employed to cover a genomic region of interest for localizing a trait locus. In this report, we propose a novel multi-marker family-based association test (T(LC)) that linearly combines the single-marker test statistics using data-driven weights. We examine the type-I error rate in a numerical study and compare its power to identify a common trait locus using tag single nucleotide polymorphisms (SNPs) within the same haplotype block that the trait locus resides with three competing tests including a global haplotype test (T(H)), a multi-marker test similar to the Hotelling-T(2) test for the population-based data (T(MM)), and a single-marker test with Bonferroni's correction for multiple testing (T(B)). The type-I error rate of T(LC) is well maintained in our numeric study. In all the scenarios we examined, T(LC) is the most powerful, followed by T(B). T(MM) and T(H) are the poorest. T(H) and T(MM) have essentially the same power when parents are available. However, when both parents are missing, T(MM) is substantially more powerful than T(H). We also apply this new test on a data set from a previous association study on nicotine dependence.

An efficient family-based association test using multiple markers. Publishing Authors By Initials

X Xu,C Rakovski,X Xu,N Laird,

For similar disorders of environmental origin: substance-related disorders: tobacco use disorder research abstracts see: disorders of environmental origin: substance-related disorders: tobacco use disorder research

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An efficient family-based association test using multiple markers. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genetic epidemiology

VOLUME: 30

Page Numbers: 620-6

Journal Abbreviation: Genet. Epidemiol.

ISSN: 0741-0395

DAY: 3

MONTH: Nov

YEAR: 2006

An efficient family-based association test using multiple markers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8411723

An efficient family-based association test using multiple markers. Keywords Mesh Terms:

KEYWORDS: Tobacco Use Disorder

MESH TERMS: genetics

Chemical & Substance for Abstract: An efficient family-based association test using multiple markers. Information

Substance Name: Genetic Markers

Registry Number: 0

Grant and Affiliation Information for An efficient family-based association test using multiple markers.

AFFILIATION: Program for Population Genetics, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. xin_xu@harvard.edu

Country: United States

AGENCY: United States NIMH

GRANT: MH 059532

ACRONYM: MH

MEDLINETA: Genet Epidemiol

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