An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response.

An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response. Research Abstract Details 

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An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response. Abstract Text:

Jamie M Bacher,Paul Schimmel,

Mistranslation in bacterial and mammalian cells leads to production of statistical proteins that are, in turn, associated with specific cell or animal pathologies, including death of bacterial cells, apoptosis of mammalian cells in culture, and neurodegeneration in the mouse. A major source of mistranslation comes from heritable defects in the editing activities of aminoacyl-tRNA synthetases. These activities clear errors of aminoacylation by deacylation of mischarged tRNAs. We hypothesized that, in addition to previously reported phenotypes in bacterial and mammalian systems, errors of aminoacylation could be mutagenic and lead to disease. As a first step in testing this hypothesis, the effect of an editing defect in a single tRNA synthetase on the accumulation of mutations in aging bacteria was investigated. A striking, statistically significant, enhancement of the mutation rate in aging bacteria was found. This enhancement comes from an increase in error-prone DNA repair through induction of the bacterial SOS response. Thus, mistranslation, as caused by an editing-defective tRNA synthetase, can lead to heritable genetic changes that could, in principle, be linked to disease.

An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response. Publishing Authors By Initials

JM Bacher,P Schimmel,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 1907-12

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 30

MONTH: 01

YEAR: 2007

An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response. Information

Substance Name: Amino Acyl-tRNA Synthetases

Registry Number: EC 6.1.1.-

Grant and Affiliation Information for An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response.

AFFILIATION: The Skaggs Institute for Chemical Biology, and Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM23562

ACRONYM: GM

MEDLINETA: Proc Natl Acad Sci U S A

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