An annulative approach to highly substituted indoles: unusual effect of phenolic additives on the success of the arylation of ketone enolates.

An annulative approach to highly substituted indoles: unusual effect of phenolic additives on the success of the arylation of ketone enolates. Research Abstract Details 

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An annulative approach to highly substituted indoles: unusual effect of phenolic additives on the success of the arylation of ketone enolates. Abstract Text:

Jennifer L Rutherford,Matthew P Rainka,Stephen L Buchwald,

A novel palladium-catalyzed arylation of ketone enolates with o-nitrohaloarenes was achieved through the addition of phenol additives. The mild reaction conditions employed allowed for the inclusion of a wide variety of functional groups in both substrates to be tolerated. The products of this reaction were then readily reductively cyclized to give highly substituted indoles in moderate to excellent overall yields.

An annulative approach to highly substituted indoles: unusual effect of phenolic additives on the success of the arylation of ketone enolates. Publishing Authors By Initials

JL Rutherford,MP Rainka,SL Buchwald,

For similar organic chemicals: phenols research abstracts see: organic chemicals: phenols research

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An annulative approach to highly substituted indoles: unusual effect of phenolic additives on the success of the arylation of ketone enolates. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 124

Page Numbers: 15168-9

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 25

MONTH: Dec

YEAR: 2002

An annulative approach to highly substituted indoles: unusual effect of phenolic additives on the success of the arylation of ketone enolates. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

An annulative approach to highly substituted indoles: unusual effect of phenolic additives on the success of the arylation of ketone enolates. Keywords Mesh Terms:

KEYWORDS: Phenols

MESH TERMS: chemistry

Chemical & Substance for Abstract: An annulative approach to highly substituted indoles: unusual effect of phenolic additives on the success of the arylation of ketone enolates. Information

Substance Name: Palladium

Registry Number: 7440-05-3

Grant and Affiliation Information for An annulative approach to highly substituted indoles: unusual effect of phenolic additives on the success of the arylation of ketone enolates.

AFFILIATION: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 46059

ACRONYM: GM

MEDLINETA: J Am Chem Soc

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