An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells.

An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Research Abstract Details 

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An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Abstract Text:

Xu-Bao Shi,Lingru Xue,Joy Yang,Ai-Hong Ma,Jianjun Zhao,Ma Xu,Clifford G Tepper,Christopher P Evans,Hsing-Jien Kung,Ralph W Devere White,Xu-Bao Shi,Lingru Xue,Joy Yang,Ai-Hong Ma,Jianjun Zhao,Ma Xu,Clifford G Tepper,Christopher P Evans,Hsing-Jien Kung,Ralph W deVere White,Xu-Bao Shi,Lingru Xue,Joy Yang,Ai-Hong Ma,Jianjun Zhao,Ma Xu,Clifford G Tepper,Christopher P Evans,Hsing-Jien Kung,Ralph W deVere White,

Although prostate cancer (CaP) is the most frequently diagnosed malignant tumor and the second leading cause of cancer deaths in American men, the mechanisms explaining the development and progression of CaP remain largely unknown. Recent studies have shown that some aberrantly expressed microRNAs (miRNAs) are involved in tumorigenesis. Although aberrant expression of certain miRNAs has been discovered in CaP, their function in this disease has not yet been defined. In this study, we found differential expression of miR-125b in androgen-dependent and independent CaP cells, as well as in benign and malignant prostate tissues. Furthermore, androgen signaling was able to up-regulate the expression of miR-125b. In addition, transfection of synthetic miR-125b stimulated androgen-independent growth of CaP cells and down-regulated the expression of Bak1. Our results suggest that miR-125b acts as an oncogene, contributing to the pathogenesis of CaP.

An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Publishing Authors By Initials

XB Shi,L Xue,J Yang,AH Ma,J Zhao,M Xu,CG Tepper,CP Evans,HJ Kung,RW Devere White,XB Shi,L Xue,J Yang,AH Ma,J Zhao,M Xu,CG Tepper,CP Evans,HJ Kung,RW deVere White,XB Shi,L Xue,J Yang,AH Ma,J Zhao,M Xu,CG Tepper,CP Evans,HJ Kung,RW deVere White,

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An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 19983-8

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 1091-6490

DAY: 3

MONTH: 12

YEAR: 2007

An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

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Grant and Affiliation Information for An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells.

AFFILIATION: Departments of Urology and Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Sacramento, CA 95817.

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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