An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif.

An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif. Research Abstract Details 

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An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif. Abstract Text:

Rodney M Dale,Benjamin F Remo,Eric C Svensson,

The FOG family of transcriptional co-factors is composed of two members in mammals: FOG-1 and FOG-2. Both have been shown to bind to GATA factors and function as transcriptional co-repressors in specific cell and promoter contexts. We have previously defined a novel repression domain localized to the N-terminus of each FOG family member, the FOG repression motif, which is necessary for FOG-mediated transcriptional repression. In this report, we describe the identification and characterization of a novel isoform of FOG-2 lacking the FOG repression motif. In contrast to full-length FOG-2, this isoform is expressed predominately in the embryonic and adult heart. It can bind GATA4 avidly, but is unable to repress GATA4-mediated activation of cardiac-restricted gene promoters. Together, these results suggest that FOG-2 repressive activity may be modulated by the generation of isoforms of FOG-2 lacking the FOG repression motif.

An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif. Publishing Authors By Initials

RM Dale,BF Remo,EC Svensson,

For similar investigative techniques: genetic techniques: gene transfer techniques: transfection research abstracts see: investigative techniques: genetic techniques: gene transfer techniques: transfection research

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An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 357

Page Numbers: 683-7

Journal Abbreviation:

ISSN: 0006-291X

DAY: 10

MONTH: 04

YEAR: 2007

An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif. Keywords Mesh Terms:

KEYWORDS: Transfection

MESH TERMS: metabolism

Chemical & Substance for Abstract: An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif. Information

Substance Name: Zfpm2 protein, mouse

Registry Number: 0

Grant and Affiliation Information for An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif.

AFFILIATION: Department of Medicine, University of Chicago, 5841 S. Maryland Avenue, MC6088, Chicago, IL 60637, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: T32 HL07381

ACRONYM: HL

MEDLINETA: Biochem Biophys Res Commun

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