An algorithm to locate hrB- donors for individuals with sickle cell disease.

An algorithm to locate hrB- donors for individuals with sickle cell disease. Research Abstract Details 

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An algorithm to locate hrB- donors for individuals with sickle cell disease. Abstract Text:

Many African Americans with sickle cell disease (SCD) develop alloantibodies to antigens in the Rh blood group system. Others have shown that from D- individuals, those lacking the high-incidence hrB antigen (> 98% prevalence) may be found among r'r African Americans. We describe an algorithm to locate units for African Americans with SCD and anti-hrB and -D. From 46,539 donations, 5136 listed African American as race. Our primary reference laboratory performed Rh phenotyping (D, C, c, E, e) for first-time donors and those not tested previously. Specimens typing r'r were sent to a secondary reference laboratory for hrB phenotyping after each donation.Hemoglobin S screening was performed.Of 24 donors (27 donations) who phenotyped r'r, seven donors,29.2 percent (nine donations) were hrB-.Two of seven who donated twice consistently tested hrB-. One of 24 donors initially tested hrB-, but hrB+ on repeat donation. The donor tested hrB- by a second reference laboratory. Reagents for phenotyping high-incidence antigens are often not readily available, requiring a specialized reference laboratory that adds cost and turnaround time. Our algorithm selected r'r African American donors most likely to lack hrB for further evaluation by a second reference laboratory.We felt this was the most judicious use of resources and provided the greatest opportunity to find compatible components for individuals with SCD and anti-hrB and -D.

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An algorithm to locate hrB- donors for individuals with sickle cell disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Immunohematology / American Red Cross

VOLUME: 18

Page Numbers: 82-4

Journal Abbreviation: Immunohematology

ISSN: 0894-203X

DAY: 8

MONTH: 04

YEAR: 2002

An algorithm to locate hrB- donors for individuals with sickle cell disease. Information

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LANGUAGE: eng

NlmUniqueID: 8806387

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Grant and Affiliation Information for An algorithm to locate hrB- donors for individuals with sickle cell disease.

AFFILIATION: South Florida Blood Banks, Inc., 933 45th Street,West Palm Beach, Florida 33407, USA. rgammon@sfbb.org

Country: United States

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MEDLINETA: Immunohematology

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