An Aging Interventions Testing Program: study design and interim report.

An Aging Interventions Testing Program: study design and interim report. Research Abstract Details 

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An Aging Interventions Testing Program: study design and interim report. Abstract Text:

Richard A Miller,David E Harrison,Clinton M Astle,Robert A Floyd,Kevin Flurkey,Kenneth L Hensley,Martin A Javors,Christiaan Leeuwenburgh,James F Nelson,Ennio Ongini,Nancy L Nadon,Huber R Warner,Randy Strong,

The National Institute on Aging's Interventions Testing Program (ITP) has developed a plan to evaluate agents that are considered plausible candidates for delaying rates of aging. Key features include: (i) use of genetically heterogeneous mice (a standardized four-way cross), (ii) replication at three test sites (the Jackson Laboratory, TJL; University of Michigan, UM; and University of Texas, UT), (iii) sufficient statistical power to detect 10% changes in lifespan, (iv) tests for age-dependent changes in T cell subsets and physical activity, and (v) an annual solicitation for collaborators who wish to suggest new interventions for evaluation. Mice in the first cohort were exposed to one of four agents: aspirin, nitroflurbiprofen (NFP), 4-OH-alpha-phenyl-N-tert-butyl nitrone (4-OH-PBN), or nordihydroguiaretic acid (NDGA). An interim analysis was conducted using survival data available on the date at which at least 50% of the male control mice had died at each test site. Survival of control males was significantly higher, at the interim time-point, at UM than at UT or TJL; all three sites had similar survival of control females. Males in the NDGA group had significantly improved survival (P = 0.0004), with significant effects noted at TJL (P < 0.01) and UT (P < 0.04). None of the other agents altered survival, although there was a suggestion (P = 0.07) of a beneficial effect of aspirin in males. More data will be needed to determine if any of these compounds can extend maximal lifespan, but the current data show that NDGA reduces early life mortality risks in genetically heterogeneous mice at multiple test sites.

An Aging Interventions Testing Program: study design and interim report. Publishing Authors By Initials

RA Miller,DE Harrison,CM Astle,RA Floyd,K Flurkey,KL Hensley,MA Javors,C Leeuwenburgh,JF Nelson,E Ongini,NL Nadon,HR Warner,R Strong,

For similar investigative techniques: epidemiologic methods: statistics as topic: survival analysis research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: survival analysis research

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An Aging Interventions Testing Program: study design and interim report. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Aging cell

VOLUME: 6

Page Numbers: 565-75

Journal Abbreviation: Aging Cell

ISSN: 1474-9718

DAY: 18

MONTH: 06

YEAR: 2007

An Aging Interventions Testing Program: study design and interim report. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101130839

An Aging Interventions Testing Program: study design and interim report. Keywords Mesh Terms:

KEYWORDS: Survival Analysis

MESH TERMS: pharmacology

Chemical & Substance for Abstract: An Aging Interventions Testing Program: study design and interim report. Information

Substance Name: Flurbiprofen

Registry Number: 5104-49-4

Grant and Affiliation Information for An Aging Interventions Testing Program: study design and interim report.

AFFILIATION: Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor VA Medical Center, Ann Arbor, MI 48109-2200, USA. millerr@umich.edu

Country: England

AGENCY: United States NIA

GRANT: AG13319

ACRONYM: AG

MEDLINETA: Aging Cell

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