An Actinobacillus pleuropneumoniae arcA deletion mutant is attenuated and deficient in biofilm formation.

An Actinobacillus pleuropneumoniae arcA deletion mutant is attenuated and deficient in biofilm formation. Research Abstract Details 

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An Actinobacillus pleuropneumoniae arcA deletion mutant is attenuated and deficient in biofilm formation. Abstract Text:

Falk F R Buettner,Alexander Maas,Gerald-F Gerlach,Falk F R Buettner,Alexander Maas,Gerald-F Gerlach,

Actinobacillus pleuropneumoniae is a facultative anaerobic pathogen of the porcine respiratory tract requiring anaerobic metabolic activity for persistence on lung epithelium. The ArcAB two-component system facilitating metabolic adaptation to anaerobicity was investigated with regard to its impact on virulence and colonization of the porcine respiratory tract. Using pig infection experiments we demonstrate that deletion of arcA renders A. pleuropneumoniae significantly attenuated in acute infection and reduced long-term survival on unaltered lung epithelium as well as in sequesters. Contrary to its role in enterobacteria, the deletion of arcA in A. pleuropneumoniae does not affect growth and survival under anaerobic conditions. Instead, other than the parent strain A. pleuropneumoniae DeltaarcA does not show autoaggregation under anaerobic conditions and is deficient in biofilm formation. It is hypothesized that the lack of these functions is, at least in part, responsible for the reduction of virulence.

An Actinobacillus pleuropneumoniae arcA deletion mutant is attenuated and deficient in biofilm formation. Publishing Authors By Initials

FF Buettner,A Maas,GF Gerlach,FF Buettner,A Maas,GF Gerlach,

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An Actinobacillus pleuropneumoniae arcA deletion mutant is attenuated and deficient in biofilm formation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Veterinary microbiology

VOLUME: 127

Page Numbers: 106-15

Journal Abbreviation: Vet. Microbiol.

ISSN: 0378-1135

DAY: 15

MONTH: 08

YEAR: 2007

An Actinobacillus pleuropneumoniae arcA deletion mutant is attenuated and deficient in biofilm formation. Information

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LANGUAGE: eng

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Grant and Affiliation Information for An Actinobacillus pleuropneumoniae arcA deletion mutant is attenuated and deficient in biofilm formation.

AFFILIATION: Institute for Microbiology, Department of Infectious Diseases, University of Veterinary Medicine Hannover, 30173 Hannover, Germany.

Country: Netherlands

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MEDLINETA: Vet Microbiol

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