An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center.

An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center. Research Abstract Details 

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An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center. Abstract Text:

Mamoru Nagano,Akihito Adachi,Ken-ichi Nakahama,Toru Nakamura,Masako Tamada,Elizabeth Meyer-Bernstein,Amita Sehgal,Yasufumi Shigeyoshi,

The suprachiasmatic nucleus (SCN) is the neuroanatomical locus of the mammalian circadian pacemaker. Here we demonstrate that an abrupt shift in the light/dark (LD) cycle disrupts the synchronous oscillation of circadian components in the rat SCN. The phases of the RNA cycles of the period genes Per1 and Per2 and the cryptochrome gene Cry1 shifted rapidly in the ventrolateral, photoreceptive region of the SCN, but were relatively slow to shift in the dorsomedial region. During the period of desynchrony, the animals displayed increased nighttime rest, the timing of which was inversely correlated with the expression of Per1 mRNA in the dorsomedial SCN. Molecular resynchrony required approximately 6 d after a 10 hr delay and 9 approximately 13 d after a 6 hr advance of the LD cycle and was accompanied by the reemergence of normal rest-activity patterns. This dissociation and slow resynchronization of endogenous oscillators within the SCN after an LD cycle shift suggests a mechanism for the physiological symptoms that constitute jet lag.

An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center. Publishing Authors By Initials

M Nagano,A Adachi,K Nakahama,T Nakamura,M Tamada,E Meyer-Bernstein,A Sehgal,Y Shigeyoshi,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of neuroscience : the official journal

VOLUME: 23

Page Numbers: 6141-51

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 9

MONTH: Jul

YEAR: 2003

An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center. Information

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LANGUAGE: eng

NlmUniqueID: 8102140

An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center. Information

Substance Name: cryptochrome protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center.

AFFILIATION: Department of Anatomy and Neurobiology, Kinki University School of Medicine, Osakasayama City, Osaka 589-8511, Japan.

Country: United States

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MEDLINETA: J Neurosci

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