Amyloid, memory and neurogenesis.

Amyloid, memory and neurogenesis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Amyloid, memory and neurogenesis. Abstract Text:

Dave Morgan,

Transgenic mouse models of amyloid deposition consistently demonstrate impaired performance on certain tasks of learning and memory. The article by Zhang et al. (2006) demonstrates reductions in dentate gyrus neurogenesis in a murine model of amyloid deposition which is linked to the deposition of amyloid and not overexpression of transgenes. Neurogenesis plays at least a facilitatory role in the formation of memory, the nature of which is only beginning to emerge. Thus, it seems reasonable to propose that the memory deficits found in the amyloid precursor protein transgenic mouse models of amyloid deposition result, at least in part, from reduced rates of hippocampal neurogenesis. The possible relationship to memory loss in Alzheimer's dementia is also discussed.

Amyloid, memory and neurogenesis. Publishing Authors By Initials

D Morgan,

For similar nervous system: neurons research abstracts see: nervous system: neurons research

PUBMED ID PMID:

MEDLINE DATE:

Amyloid, memory and neurogenesis. Journal Published:

PUBLICATION TYPE: Review

Journal: Experimental neurology

VOLUME: 205

Page Numbers: 330-5

Journal Abbreviation: Exp. Neurol.

ISSN: 0014-4886

DAY: 14

MONTH: 03

YEAR: 2007

Amyloid, memory and neurogenesis. Information

Number of References: 74

LANGUAGE: eng

NlmUniqueID: 370712

Amyloid, memory and neurogenesis. Keywords Mesh Terms:

KEYWORDS: Neurons

MESH TERMS: physiology

Chemical & Substance for Abstract: Amyloid, memory and neurogenesis. Information

Substance Name: Amyloid

Registry Number: 0

Grant and Affiliation Information for Amyloid, memory and neurogenesis.

AFFILIATION: Alzheimer Research Laboratory, Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, 12901 BB Downs Blvd. MDC Box 9, University of South Florida, Tampa, FL 33612, USA. scientist.dave@gmail.com

Country: United States

AGENCY: United States NINDS

GRANT: NS48335

ACRONYM: NS

MEDLINETA: Exp Neurol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Amyloid, memory and neurogenesis Related Publications

• A Methodology for Comparing Results from Two Image Registration Systems used in MR-based Radiotherapy.
• A computer model to simulate control of parasitic gastroenteritis in sheep on UK farms.
• A left upper lobe tumour mimicking tracheal stenosis on plain chest x-ray.
• A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability.
• Abortive activation precedes functional deletion of CD8+ T cells following encounter with self-antigens expressed by resting B cells in vivo.
• An Introduction to Dermatological Surgery, 2nd edn.
• BMPs mediate lateral inhibition at successive stages in feather tract development.
• Barbiturates for acute neurological and neurosurgical emergencies - do they still have a role?
• Behavioral and electrophysiological evidence for opioid tolerance in adolescent rats.
• Cbln1 is essential for interaction-dependent secretion of Cbln3.
• Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase.
• Dysarthria and dysphagia following treatment for a fourth ventricle choroid plexus papilloma.
• Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability.
• FEV(1) or peak flow for measuring airflow obstruction in primary care Is it a useful debate or just missing the point?
• Focal adhesion signaling is required for myometrial ERK activation and contractile phenotype switch before labor.
• Immune, health and endocrine characteristics of depressed postpartum mothers.
• Internet chat rooms: connecting with a new generation of young men of color at risk for HIV infection who have sex with other men.
• Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review.
• Mitochondrial respiration and reactive oxygen species in C. elegans.
• Off-pump repair of a post-infarct ventricular septal defect: the 'Hamburger procedure'.
• Parenteral nutrition in the preterm infant.
• RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia.
• Radioimmunoassay for the quantitative determination of quinine in cultured plant tissues.
• Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake.
• Sarcoptes scabiei (Acari: Sarcoptidae) mite extract modulates expression of cytokines and adhesion molecules by human dermal microvascular endothelial cells.
• Science signals a new understanding of marihuana.
• Sulfated signal from ASJ sensory neurons modulates stomatin-dependent coordination in Caenorhabditis elegans.
• Targeted and nontargeted effects of low-dose ionizing radiation on delayed genomic instability in human cells.
• Temporal mRNA profiles of inflammatory mediators in the murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine model of Parkinson's disease.
• Vaccination of Tamarin with Recombinant Vaccinia Virus Expressing Epstein Barr Virus (EBV) Latent Proteins.