Amyloid-beta E22Delta variant induces synaptic alteration in mouse hippocampal slices.

Amyloid-beta E22Delta variant induces synaptic alteration in mouse hippocampal slices. Research Abstract Details 

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Amyloid-beta E22Delta variant induces synaptic alteration in mouse hippocampal slices. Abstract Text:

Hiroshi Takuma,Rie Teraoka,Hiroshi Mori,Takami Tomiyama,

We recently identified a novel amyloid precursor protein mutation (E693Delta) in familial Alzheimer's-type dementia. This mutation produces amyloid-beta (Abeta) variant lacking glutamate-22 (E22Delta), which showed enhanced oligomerization but no fibrillization. Here, we examined in-vitro toxicity of Abeta E22Delta peptide. Wild-type Abeta1-42 showed a dose-dependent (1 nM to 1 muM) cytotoxicity to cultured neuronal cells in the 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromide assay, whereas Abeta1-42 E22Delta was toxic only weakly at 1 muM. In mouse hippocampal slices, however, Abeta1-42 E22Delta caused a dose-dependent (0.1-10 muM) decrease of synaptophysin, whereas wild-type Abeta1-42 was trophic at 0.1-1 muM and toxic at 10 muM. These results suggest that extracellular Abeta E22Delta causes more potent synaptic alteration, but lower neurodegeneration, than wild-type Abeta probably because of its unique aggregation property.

Amyloid-beta E22Delta variant induces synaptic alteration in mouse hippocampal slices. Publishing Authors By Initials

H Takuma,R Teraoka,H Mori,T Tomiyama,

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Amyloid-beta E22Delta variant induces synaptic alteration in mouse hippocampal slices. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuroreport

VOLUME: 19

Page Numbers: 615-9

Journal Abbreviation: Neuroreport

ISSN: 0959-4965

DAY: 15

MONTH: Apr

YEAR: 2008

Amyloid-beta E22Delta variant induces synaptic alteration in mouse hippocampal slices. Information

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LANGUAGE: eng

NlmUniqueID: 9100935

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AFFILIATION: Department of Neuroscience, Osaka City University Graduate School of Medicine, Osaka, Japan.

Country: England

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MEDLINETA: Neuroreport

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