Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies.

Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies. Abstract Text:

Amoxicillin is recommended for anthrax prevention in pregnancy. The objective of this study was to evaluate the pharmacokinetics of amoxicillin during pregnancy and postpartum (PP). Sixteen women received amoxicillin during gestation (18-22 weeks (T2) and 30-34 weeks (T3)) as well as 3 months postpartum (PP) to evaluate single-dose pharmacokinetics. Amoxicillin compartmental pharmacokinetic parameters were used to simulate amoxicillin concentration-time profiles following different dosage strategies. Amoxicillin CL(renal) (T2: 24.8+/-6.7 l/h, P<0.001; T3: 24.0+/-3.9 l/h, P<0.001; and PP: 15.3+/-2.6 l/h) and renal CL(secretion) (T2: 280+/-105 ml/min, P<0.002; T3: 259+/-54 ml/min, P<0.001; and PP: 167+/-47 ml/min) were higher during pregnancy than postpartum. Simulations suggest that amoxicillin concentrations adequate to prevent anthrax may be difficult to achieve during pregnancy and postpartum. Increases in amoxicillin CL(renal) and renal CL(secretion) reflect increases in filtration and secretory transport or diminished reabsorption in the kidneys. Amoxicillin may not be an appropriate antibiotic for post-anthrax exposure prophylaxis.

Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies. Publishing Authors By Initials

For similar reproductive and urinary physiology: reproduction: pregnancy: pregnancy trimesters: pregnancy trimester, third research abstracts see: reproductive and urinary physiology: reproduction: pregnancy: pregnancy trimesters: pregnancy trimester, third research

PUBMED ID PMID:

MEDLINE DATE:

Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Clinical pharmacology and therapeutics

VOLUME: 81

Page Numbers: 547-56

Journal Abbreviation: Clin. Pharmacol. Ther.

ISSN: 0009-9236

DAY: 28

MONTH: 02

YEAR: 2007

Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372741

Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies. Keywords Mesh Terms:

KEYWORDS: Pregnancy Trimester, Third

MESH TERMS: metabolism

Chemical & Substance for Abstract: Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies. Information

Substance Name: Amoxicillin

Registry Number: 26787-78-0

Grant and Affiliation Information for Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies.

AFFILIATION: Department of Bioengineering, University of Washington, Seattle, Washington, USA.

Country: United States

AGENCY: United States NIBIB

GRANT: P41 EB001975

ACRONYM: EB

MEDLINETA: Clin Pharmacol Ther

REFSOURCE: Clin Pharmacol Ther. 2007 Apr;81(4):481-

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies Related Publications

• Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies.
• Analysis of protein folding and oxidation in the endoplasmic reticulum.
• Anti-beta1AR antibodies in dilated cardiomyopathy: are these a new class of receptor agonists?
• Biomarker discovery in human SLE nephritis.
• Comparisons of Models of Cognitive Strategies During a Cycling Maximal Test and Simulated Time Trial: 2265: Board #178 June 1 9:00 AM - 10:30 AM.
• Design and applicability of DNA arrays and DNA barcodes in biodiversity monitoring.
• Differential effects of polyglutamine proteins on nuclear organization and artificial reporter splicing.
• Fluctuation in self-perceived stress and increased risk of flare in patients with lupus nephritis carrying the serotonin receptor 1A -1019 G allele.
• Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha(s).
• It's time to take back the health care debate.
• Median filtering in constant time.
• Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly.
• N-linked carbohydrates act as lumenal maturation and quality control protein tags.
• Nanocarbon as robust catalyst: mechanistic insight into carbon-mediated catalysis.
• Potential use of DNA barcodes in regulatory science: applications of the Regulatory Fish Encyclopedia.
• SV40 VP2 and VP3 insertion into ER membranes is controlled by the capsid protein VP1: implications for DNA translocation out of the ER.
• Single particle refinement in electron crystallography: A pilot study.
• Spot urine protein/creatinine ratios are unreliable estimates of 24 h proteinuria in most systemic lupus erythematosus nephritis flares.
• Thiazide diuretic monotherapy for hypertension: Diuretic's dark side just got darker.
• Urine concentrating defect in prostaglandin EP1-deficient mice.
• Usual ACE inhibitor therapy in CKD patients is associated with lower plasma aldosterone levels than usual angiotensin receptor blocker therapy.
• What's new in Nicotine & Tobacco Research?
• What's new in Nicotine & Tobacco Research?
• What's new in Nicotine & Tobacco Research?
• What's new in Nicotine & Tobacco Research?
• What's new in Nicotine & Tobacco Research?
• What's new in nicotine & tobacco research?
• [Not Available.]
• [Not Available.]
• [Not Available.]