Amnesia produced by altered release of neurotransmitters after intraamygdala injections of a protein synthesis inhibitor.

Amnesia produced by altered release of neurotransmitters after intraamygdala injections of a protein synthesis inhibitor. Research Abstract Details 

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Amnesia produced by altered release of neurotransmitters after intraamygdala injections of a protein synthesis inhibitor. Abstract Text:

Clinton E Canal,Qing Chang,Paul E Gold,

Amnesia produced by protein synthesis inhibitors such as anisomycin provides major support for the prevalent view that the formation of long-lasting memories requires de novo protein synthesis. However, inhibition of protein synthesis might disrupt other neural functions to interfere with memory formation. Intraamygdala injections of anisomycin before inhibitory avoidance training impaired memory in rats tested 48 h later. Release of norepinephrine (NE), dopamine (DA), and serotonin, measured at the site of anisomycin infusions, increased quickly by approximately 1,000-17,000%, far above the levels seen under normal conditions. NE and DA release later decreased far below baseline for several hours before recovering at 48 h. Intraamygdala injections of a beta-adrenergic receptor antagonist or agonist, each timed to blunt effects of increases and decreases in NE release after anisomycin, attenuated anisomycin-induced amnesia. In addition, similar to the effects on memory seen with anisomycin, intraamygdala injections of a high dose of NE before training impaired memory tested at 48 h after training. These findings suggest that altered release of neurotransmitters may mediate amnesia produced by anisomycin and, further, raise important questions about the empirical bases for many molecular theories of memory formation.

Amnesia produced by altered release of neurotransmitters after intraamygdala injections of a protein synthesis inhibitor. Publishing Authors By Initials

CE Canal,Q Chang,PE Gold,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Amnesia produced by altered release of neurotransmitters after intraamygdala injections of a protein synthesis inhibitor. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 12500-5

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 18

MONTH: 07

YEAR: 2007

Amnesia produced by altered release of neurotransmitters after intraamygdala injections of a protein synthesis inhibitor. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

Amnesia produced by altered release of neurotransmitters after intraamygdala injections of a protein synthesis inhibitor. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: secretion

Chemical & Substance for Abstract: Amnesia produced by altered release of neurotransmitters after intraamygdala injections of a protein synthesis inhibitor. Information

Substance Name: Dopamine

Registry Number: 51-61-6

Grant and Affiliation Information for Amnesia produced by altered release of neurotransmitters after intraamygdala injections of a protein synthesis inhibitor.

AFFILIATION: Neuroscience Program, Department of Animal Sciences, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA.

Country: United States

AGENCY: United States NIDA

GRANT: DA16951

ACRONYM: DA

MEDLINETA: Proc Natl Acad Sci U S A

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