[Aminopeptidase inhibitor Bestatin induces HL-60 cell apoptosis through activating caspase 3]

[Aminopeptidase inhibitor Bestatin induces HL-60 cell apoptosis through activating caspase 3] Research Abstract Details 

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[Aminopeptidase inhibitor Bestatin induces HL-60 cell apoptosis through activating caspase 3] Abstract Text:

M Lin,J He,Z Cai,W Qian,

OBJECTIVE: To study the variation and significance of caspase 3 activity in the process of amino-peptidase inhibitor--bestatin (BS) inducing human leukemic cell apoptosis. METHODS: Cell apoptosis was evaluated by light microscopy, TUNEL labeling and flow cytometry (FCM). Caspase 3 activity was detected by colorimetry. The mitochondrial transmembrane potentials (DeltaPsi(m)) were detected by Rhodamine123 staining. RESULTS: The apoptotic morphology, apoptotic peak on FCM and positive Annexin V(FITC) on cell membrane showed that BS could induce HL-60 cell apoptosis in a dose- and time-dependent manner. Caspase 3 activity was significantly higher in the apoptotic cells than in control cells. The apoptosis induced by BS was inhibited by AC-DEVD-CHO. The DeltaPsi(m) of cells treated with BS declined. CONCLUSION: BS induces apoptosis of human acute leukemic cells through activation of caspase 3.

[Aminopeptidase inhibitor Bestatin induces HL-60 cell apoptosis through activating caspase 3] Publishing Authors By Initials

M Lin,J He,Z Cai,W Qian,

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[Aminopeptidase inhibitor Bestatin induces HL-60 cell apoptosis through activating caspase 3] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 22

Page Numbers: 348-50

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 5

MONTH: Jul

YEAR: 2001

[Aminopeptidase inhibitor Bestatin induces HL-60 cell apoptosis through activating caspase 3] Information

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LANGUAGE: chi

NlmUniqueID: 8212398

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AFFILIATION: Department of Hematology, First Hospital of Medical Institute of Zhejiang University, Hangzhou 310003, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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