Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage.

Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. Abstract Text:

Eisuke Itakura,Kaori Kajihara Takai,Kazuyuki Umeda,Makoto Kimura,Mariko Ohsumi,Katsuyuki Tamai,Akira Matsuura,

ATM and rad3-related protein kinase (ATR), a member of the phosphoinositide kinase-like protein kinase family, plays a critical role in cellular responses to DNA structural abnormalities in conjunction with its interacting protein, ATRIP. Here, we show that the amino-terminal portion of ATRIP is relocalized to DNA damage-induced nuclear foci in an RPA-dependent manner, despite its lack of ability to associate with ATR. In addition, ATR-free ATRIP protein can be recruited to the nuclear foci. Our results suggest that the N-terminal domain of the ATRIP protein contributes to the cell cycle checkpoint by regulating the intranuclear localization of ATR.

Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. Publishing Authors By Initials

E Itakura,KK Takai,K Umeda,M Kimura,M Ohsumi,K Tamai,A Matsuura,

For similar nucleic acids, nucleotides, and nucleosides: antisense elements (genetics): rna, antisense: rna, small interfering research abstracts see: nucleic acids, nucleotides, and nucleosides: antisense elements (genetics): rna, antisense: rna, small interfering research

PUBMED ID PMID:

MEDLINE DATE:

Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: FEBS letters

VOLUME: 577

Page Numbers: 289-93

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 5

MONTH: Nov

YEAR: 2004

Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 155157

Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. Keywords Mesh Terms:

KEYWORDS: RNA, Small Interfering

MESH TERMS: physiology

Chemical & Substance for Abstract: Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. Information

Substance Name: three prime repair exonuclease 1

Registry Number: EC 3.1.16.-

Grant and Affiliation Information for Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage.

AFFILIATION: Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi 474-8522, Japan.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: FEBS Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage Related Publications

• ATR-dependent phosphorylation of ATRIP in response to genotoxic stress.
• Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage.
• An ability of isolated strains to efficiently cooperate in ethanolic fermentation of agricultural plant refuse under initially aerobic thermophilic conditions: Oxygen deletion process appended to consolidated bioprocessing (CBP).
• Analysis of lectin properties with membrane ultrafiltration and high-pressure liquid chromatography.
• Analytical method for sugar chain structures involving lectins and membrane ultrafiltration.
• Angiography of abdominal lymphomas.
• Determination of procalcitonin concentration using the SphereLight 180 clinical auto-analyzer.
• Dethiosulfatibacter aminovorans gen. nov., sp. nov., a novel thiosulfate-reducing bacterium isolated from coastal marine sediment via sulfate-reducing enrichment with Casamino acids.
• Distinguished effects of antiphospholipid antibodies and anti-oxidized LDL antibodies on oxidized LDL uptake by macrophages.
• Evaluation systems for anti-HCV drugs.
• Furanoditerpenes of Fibraurea chloroleuca.
• Gonyautoxin associated with RNA-containing fraction in the toxic scallop digestive gland.
• Groove pancreatitis associated with true pancreatic cyst.
• Intracellular trafficking of beta2-glycoprotein I complexes with lipid vesicles in macrophages: implications on the development of antiphospholipid syndrome.
• Monoclonal antibody for calcitriol (1 alpha,25-dihydroxyvitamin D3).
• Myotonic dystrophy type 2 in Japan: ancestral origin distinct from Caucasian families.
• Nontoxic and chemically stable hollow optical fiber probe for fourier transform infrared spectroscopy.
• Optimal pulse sequences for magnetic resonance imaging-computing accurate t1, t2, and proton density images.
• Single-step coating of mesoporous silica on cetyltrimethyl ammonium bromide-capped nanoparticles.
• Surgical treatment of infected intralobar pulmonary sequestration: a collective review of patients older than 50 years reported in the literature.
• Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials.
• The chain compositions of several invertebrate collagens.
• The identification of aminoalkylphosphonyl cerebrosides in the marine gastropod, Monodonta labio.
• Three-dimensional imaging of traumatic multiple fractures of the thorax by multislice computed tomography.
• Three-dimensional structure of ferricytochrome c' from Rhodospirillum rubrum at 2.8 A resolution.
• TopBP1 associates with NBS1 and is involved in homologous recombination repair.
• [A case with a single liver metastasis from pancreatic cancer surviving for 29 months]
• [Motivation of nursing students and economic changes]
• [Renal cell carcinoma presenting high serum level of CA19-9 due to hydronephrosis: a case report]
• [Triple cancer in the urinary system: a case report]