Amino acids and immune function.

Amino acids and immune function. Research Abstract Details 

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Amino acids and immune function. Abstract Text:

Peng Li,Yu-Long Yin,Defa Li,Sung Woo Kim,Guoyao Wu,

A deficiency of dietary protein or amino acids has long been known to impair immune function and increase the susceptibility of animals and humans to infectious disease. However, only in the past 15 years have the underlying cellular and molecular mechanisms begun to unfold. Protein malnutrition reduces concentrations of most amino acids in plasma. Findings from recent studies indicate an important role for amino acids in immune responses by regulating: (1) the activation of T lymphocytes, B lymphocytes, natural killer cells and macrophages; (2) cellular redox state, gene expression and lymphocyte proliferation; and (3) the production of antibodies, cytokines and other cytotoxic substances. Increasing evidence shows that dietary supplementation of specific amino acids to animals and humans with malnutrition and infectious disease enhances the immune status, thereby reducing morbidity and mortality. Arginine, glutamine and cysteine precursors are the best prototypes. Because of a negative impact of imbalance and antagonism among amino acids on nutrient intake and utilisation, care should be exercised in developing effective strategies of enteral or parenteral provision for maximum health benefits. Such measures should be based on knowledge about the biochemistry and physiology of amino acids, their roles in immune responses, nutritional and pathological states of individuals and expected treatment outcomes. New knowledge about the metabolism of amino acids in leucocytes is critical for the development of effective means to prevent and treat immunodeficient diseases. These nutrients hold great promise in improving health and preventing infectious diseases in animals and humans.

Amino acids and immune function. Publishing Authors By Initials

P Li,YL Yin,D Li,SW Kim,G Wu,

For similar nutritional and metabolic diseases: nutrition disorders research abstracts see: nutritional and metabolic diseases: nutrition disorders research

PUBMED ID PMID:

MEDLINE DATE:

Amino acids and immune function. Journal Published:

PUBLICATION TYPE: Review

Journal: The British journal of nutrition

VOLUME: 98

Page Numbers: 237-52

Journal Abbreviation: Br. J. Nutr.

ISSN: 0007-1145

DAY: 3

MONTH: 04

YEAR: 2007

Amino acids and immune function. Information

Number of References: 165

LANGUAGE: eng

NlmUniqueID: 372547

Amino acids and immune function. Keywords Mesh Terms:

KEYWORDS: Nutrition Disorders

MESH TERMS: immunology

Chemical & Substance for Abstract: Amino acids and immune function. Information

Substance Name: Dietary Proteins

Registry Number: 0

Grant and Affiliation Information for Amino acids and immune function.

AFFILIATION: Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station, TX 77843, USA.

Country: England

AGENCY: United States NICHD

GRANT: R21 HD049449

ACRONYM: HD

MEDLINETA: Br J Nutr

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