Amelioration of mercury-induced autoimmunity by 4-1BB.

Amelioration of mercury-induced autoimmunity by 4-1BB. Research Abstract Details 

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Amelioration of mercury-induced autoimmunity by 4-1BB. Abstract Text:

Dass S Vinay,Jung D Kim,Byoung S Kwon,

In certain strains of mice, subtoxic doses of HgCl2 (mercuric chloride; mercury) induce a complex autoimmune condition characterized by the production of antinucleolar IgG Abs, lymphoproliferation, increased serum levels of IgG1/IgE Abs, and deposition of renal immune complexes. 4-1BB is an important T cell costimulatory molecule that has been implicated in T cell proliferation and cytokine production, especially production of IFN-gamma. To elucidate T cell control mediated by the 4-1BB signaling pathway in this syndrome, we assessed the effect of administering agonistic anti-4-1BB mAb on mercury-induced autoimmunity. Groups of A.SW mice (H-2s) received mercury/control Ig or mercury/anti-4-1BB or PBS alone. Anti-4-1BB mAb treatment resulted in a dramatic reduction of mercury-induced antinucleolar Ab titers, serum IgG1/IgE induction, and renal Ig deposition. These effects may be related to the present finding that anti-4-1BB mAb decreases B cell numbers and function. The anti-4-1BB mAb-treated mercury group also showed a marked reduction in Th2-type cytokines but an increase in Th1-type cytokines and chemokines. Increased IFN-gamma production due to anti-4-1BB mAb treatment appears to be responsible for the observed B cell defects because neutralization of IFN-gamma in vivo substantially restored B cell numbers and partly restored IgG1/IgE. Collectively, our results indicate that 4-1BB mAb can down-regulate mercury-induced autoimmunity by affecting B cell function in an IFN-gamma-dependent manner and thus, preventing the development of autoantibody production and tissue Ig deposition.

Amelioration of mercury-induced autoimmunity by 4-1BB. Publishing Authors By Initials

DS Vinay,JD Kim,BS Kwon,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: mice research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: mice research

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MEDLINE DATE:

Amelioration of mercury-induced autoimmunity by 4-1BB. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 177

Page Numbers: 5708-17

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Oct

YEAR: 2006

Amelioration of mercury-induced autoimmunity by 4-1BB. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Amelioration of mercury-induced autoimmunity by 4-1BB. Keywords Mesh Terms:

KEYWORDS: Mice

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Amelioration of mercury-induced autoimmunity by 4-1BB. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Amelioration of mercury-induced autoimmunity by 4-1BB.

AFFILIATION: Louisiana State University Eye Center, Louisiana State University Health Science Center School of Medicine, New Orleans, LA 70112, USA.

Country: United States

AGENCY: United States NEI

GRANT: R01EY013325

ACRONYM: EY

MEDLINETA: J Immunol

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