Ambient manganese exposure is negatively associated with human sperm motility and concentration.

Ambient manganese exposure is negatively associated with human sperm motility and concentration. Research Abstract Details 

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Ambient manganese exposure is negatively associated with human sperm motility and concentration. Abstract Text:

Julia J Wirth,Mary G Rossano,Douglas C Daly,Nigel Paneth,Elizabeth Puscheck,Rachel C Potter,Michael P Diamond,

BACKGROUND: Occupational and experimental animal studies indicate that exposure to high levels of manganese impairs male fertility, but the effects of ambient manganese in humans are not known. METHODS: We measured blood levels of manganese and selenium in 200 infertility clinic clients in a cross-sectional study. Correlations between metals and semen variables were determined, adjusting for other risk factors. Outcomes were low motility (<50% motile), low concentration (<20 million/mL), or low morphology (<4% normal). We also investigated dose-response relationships between quartiles of manganese exposure and sperm parameters. RESULTS: High manganese level was associated with increased risk of low sperm motility (odds ratio = 5.4; 95% confidence interval = 1.6-17.6) and low sperm concentration (2.4; 1.2-4.9). We saw a U-shaped dose-response pattern between quartiles of manganese exposure and all 3 sperm parameters. CONCLUSION: Ambient exposure to manganese levels is associated with a reduction in sperm motility and concentration. No adverse effects were seen for high selenium.

Ambient manganese exposure is negatively associated with human sperm motility and concentration. Publishing Authors By Initials

JJ Wirth,MG Rossano,DC Daly,N Paneth,E Puscheck,RC Potter,MP Diamond,

For similar urogenital system: genitalia: germ cells: spermatozoa research abstracts see: urogenital system: genitalia: germ cells: spermatozoa research

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MEDLINE DATE:

Ambient manganese exposure is negatively associated with human sperm motility and concentration. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Epidemiology (Cambridge, Mass.)

VOLUME: 18

Page Numbers: 270-3

Journal Abbreviation:

ISSN: 1044-3983

DAY: 3

MONTH: Mar

YEAR: 2007

Ambient manganese exposure is negatively associated with human sperm motility and concentration. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9009644

Ambient manganese exposure is negatively associated with human sperm motility and concentration. Keywords Mesh Terms:

KEYWORDS: Spermatozoa

MESH TERMS: abnormalities

Chemical & Substance for Abstract: Ambient manganese exposure is negatively associated with human sperm motility and concentration. Information

Substance Name: Selenium

Registry Number: 7782-49-2

Grant and Affiliation Information for Ambient manganese exposure is negatively associated with human sperm motility and concentration.

AFFILIATION: Department of Epidemiology, Michigan State University, East Lansing, Michigan 48823, USA. wirthj@msu.edu

Country: United States

AGENCY: United States NIEHS

GRANT: E01 ES11856

ACRONYM: ES

MEDLINETA: Epidemiology

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