Alzheimer disease and the role of free radicals in the pathogenesis of the disease.

Alzheimer disease and the role of free radicals in the pathogenesis of the disease. Research Abstract Details 

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Alzheimer disease and the role of free radicals in the pathogenesis of the disease. Abstract Text:

Paula I Moreira,Maria S Santos,Catarina R Oliveira,Justin C Shenk,Akihiko Nunomura,Mark A Smith,Xiongwei Zhu,George Perry,

Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. All classes of macromolecules (sugar, lipids, proteins, and nucleic acids) are affected by oxidative stress leading, inevitably, to neuronal dysfunction. Extensive data from the literature support the notion that mitochondrial and metal abnormalities are key sources of oxidative stress in Alzheimer disease. Furthermore, it has been suggested that in the initial stages of the development of Alzheimer disease, amyloid-beta deposition and hyperphosphorylated tau function as compensatory responses to ensure that neuronal cells do not succumb to oxidative damage. However, during the progression of the disease, the antioxidant activity of both agents is either overwhelmed or, according to others, evolves into pro-oxidant activity resulting in the exacerbation of reactive species production.

Alzheimer disease and the role of free radicals in the pathogenesis of the disease. Publishing Authors By Initials

PI Moreira,MS Santos,CR Oliveira,JC Shenk,A Nunomura,MA Smith,X Zhu,G Perry,

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Alzheimer disease and the role of free radicals in the pathogenesis of the disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: CNS & neurological disorders drug targets

VOLUME: 7

Page Numbers: 3-10

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ISSN: 1871-5273

DAY: 21

MONTH: Feb

YEAR: 2008

Alzheimer disease and the role of free radicals in the pathogenesis of the disease. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Alzheimer disease and the role of free radicals in the pathogenesis of the disease.

AFFILIATION: College of Sciences, University of Texas at San Antonio, San Antonio, Texas 78249, USA. george.perry@utsa.edu.

Country: United Arab Emirates

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MEDLINETA: CNS Neurol Disord Drug Targets

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