Alveolar bone regeneration using absorbable poly(L-lactide-co-varepsilon-caprolactone)/beta-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth factor.

Alveolar bone regeneration using absorbable poly(L-lactide-co-varepsilon-caprolactone)/beta-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth factor. Research Abstract Details 

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Alveolar bone regeneration using absorbable poly(L-lactide-co-varepsilon-caprolactone)/beta-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth factor. Abstract Text:

The aim of this study was to evaluate the effects of combining a porous poly(L-lactide-co-varepsilon-caprolactone)/beta-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblastic growth factor (bFGF) on bone regeneration in mandibular ridges. Four full-thickness saddle-type defects (10mm longx5mm deep) were symmetrically created in both edentulous mandibular alveolar ridges of 6 beagles. The dome-shaped membrane was secured to each defect site, and a gelatin sponge containing 200mug bFGF was implanted on the left side of each defect (experimental group). Only the membranes (control group) were secured to the defect sites on the right. Three and 6 months later, 3 animals were killed. Bone regeneration was analyzed by soft X-ray photographs, micro-computed tomography (CT) images, and peripheral quantitative CT (pQCT), and then examined histologically. Soft X-ray examination revealed an increase in new bone volume in the experimental group 6 months postoperatively. pQCT showed that immature bone density was higher in the experimental group. Micro-CT images revealed well formed new bone along the original contour of the dome-shaped membrane in the experimental group. Histologically, inflammatory infiltration of tissue surrounding the membranes was slight. These results suggest that combining the poly(L-lactide-co-varepsilon-caprolactone)/beta-tricalcium phosphate membrane and bFGF-gelatin sponge is promising for alveolar ridge reconstruction.

Alveolar bone regeneration using absorbable poly(L-lactide-co-varepsilon-caprolactone)/beta-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth factor. Publishing Authors By Initials

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Alveolar bone regeneration using absorbable poly(L-lactide-co-varepsilon-caprolactone)/beta-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth factor. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of oral and maxillofacial su

VOLUME: 37

Page Numbers: 275-81

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ISSN: 0901-5027

DAY: 11

MONTH: 02

YEAR: 2008

Alveolar bone regeneration using absorbable poly(L-lactide-co-varepsilon-caprolactone)/beta-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth factor. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Alveolar bone regeneration using absorbable poly(L-lactide-co-varepsilon-caprolactone)/beta-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblast growth factor.

AFFILIATION: Institute for Frontier Oral Science, Kanagawa Dental College, Yokosuka, Kanagawa, Japan.

Country: Denmark

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MEDLINETA: Int J Oral Maxillofac Surg

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