Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells.

Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells. Research Abstract Details 

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Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells. Abstract Text:

Yongbae Kim,Luisa Olivi,Jae Hoon Cheong,Alex Maertens,Joseph P Bressler,

Aluminum and other trivalent metals were shown to stimulate uptake of transferrin bound iron and nontransferrin bound iron in erytholeukemia and hepatoma cells. Because of the association between aluminum and Alzheimer's Disease, and findings of higher levels of iron in Alzheimer's disease brains, the effects of aluminum on iron homeostasis were examined in a human glial cell line. Aluminum stimulated dose- and time-dependent uptake of nontransferrin bound iron and iron bound to transferrin. A transporter was likely involved in the uptake of nontransferrin iron because uptake reached saturation, was temperature-dependent, and attenuated by inhibitors of protein synthesis. Interestingly, the effects of aluminum were not blocked by inhibitors of RNA synthesis. Aluminum also decreased the amount of iron bound to ferritin though it did not affect levels of divalent metal transporter 1. These results suggest that aluminum disrupts iron homeostasis in the brain by several mechanisms including the transferrin receptor, a nontransferrin iron transporter, and ferritin.

Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells. Publishing Authors By Initials

Y Kim,L Olivi,JH Cheong,A Maertens,JP Bressler,

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: pyrimidines: pyrimidine nucleosides: tunicamycin research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: pyrimidines: pyrimidine nucleosides: tunicamycin research

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Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Toxicology and applied pharmacology

VOLUME: 220

Page Numbers: 349-56

Journal Abbreviation:

ISSN: 0041-008X

DAY: 9

MONTH: 02

YEAR: 2007

Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells. Information

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LANGUAGE: eng

NlmUniqueID: 416575

Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells. Keywords Mesh Terms:

KEYWORDS: Tunicamycin

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells. Information

Substance Name: aluminum chloride

Registry Number: 7446-70-0

Grant and Affiliation Information for Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells.

AFFILIATION: Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, USA.

Country: United States

AGENCY: United States PHS

GRANT: 03819

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MEDLINETA: Toxicol Appl Pharmacol

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