Aluminum hydroxide associated to Schistosoma mansoni 22.6 kDa protein abrogates partial protection against experimental infection but not alter interleukin-10 production.

Aluminum hydroxide associated to Schistosoma mansoni 22.6 kDa protein abrogates partial protection against experimental infection but not alter interleukin-10 production. Research Abstract Details 

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Aluminum hydroxide associated to Schistosoma mansoni 22.6 kDa protein abrogates partial protection against experimental infection but not alter interleukin-10 production. Abstract Text:

Lucila G G ,Cristina T Fonseca,Michele M Barsante,Luciana S Cardoso,Maria Ilma , Oliveira,Lucila G G Pacífico,Cristina T Fonseca,Michele M Barsante,Luciana S Cardoso,Maria Ilma Araújo,Sérgio C Oliveira,

The need to develop a vaccine against schistosomiasis led several researches and our group to investigate proteins from Schistosoma mansoni as vaccine candidates. Sm22.6 is a protein from S. mansoni that shows high identity with Sj22.6 and Sh22.6 (79 and 91%, respectively). These proteins are associated with high levels of IgE and protection to reinfection. Previously, we have shown that Sm22.6 induced a partial protection of 34.5% when used together with Freund's adjuvant and produced a Th0 type of immune response with interferon-g and interleukin-4. In this work, mice were immunized with Sm22.6 alone or with aluminum hydroxide adjuvant and high levels of IgG, IgG1, and IgG2a were measured. Unfortunately, no protection was detected. Since IL-10 is a modulating cytokine in schistosomiasis, we also observed a high level of this molecule in splenocytes of vaccinated mice. In conclusion, we did not observe the adjuvant effect of aluminum hydroxide associated with rSm22.6 in protective immunity.

Aluminum hydroxide associated to Schistosoma mansoni 22.6 kDa protein abrogates partial protection against experimental infection but not alter interleukin-10 production. Publishing Authors By Initials

LG ,CT Fonseca,MM Barsante,LS Cardoso,MI ,SC Oliveira,LG Pacífico,CT Fonseca,MM Barsante,LS Cardoso,MI Araújo,SC Oliveira,

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Aluminum hydroxide associated to Schistosoma mansoni 22.6 kDa protein abrogates partial protection against experimental infection but not alter interleukin-10 production. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Memórias do Instituto Oswaldo Cruz

VOLUME: 101 Suppl 1

Page Numbers: 365-8

Journal Abbreviation: Mem. Inst. Oswaldo Cruz

ISSN: 0074-0276

DAY: 19

MONTH: Sep

YEAR: 2006

Aluminum hydroxide associated to Schistosoma mansoni 22.6 kDa protein abrogates partial protection against experimental infection but not alter interleukin-10 production. Information

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LANGUAGE: eng

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AFFILIATION: Departamento de Bioquímica e Imunologia, Instituto de Investigação em Imunologia, Instituto Millennium, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil.

Country: Brazil

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MEDLINETA: Mem Inst Oswaldo Cruz

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