Alternative splicing within the human cytochrome P450 superfamily with an emphasis on the brain: The convolution continues.

Alternative splicing within the human cytochrome P450 superfamily with an emphasis on the brain: The convolution continues. Research Abstract Details 

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Alternative splicing within the human cytochrome P450 superfamily with an emphasis on the brain: The convolution continues. Abstract Text:

Cheri M Turman,Jade M Hatley,Daniel J Ryder,Vijayalakshmi Ravindranath,Henry W Strobel,

The human cytochrome P450 (CYP) superfamily of enzymes regulate hepatic phase 1 drug metabolism and subsequently play a significant role in pharmacokinetics, drug discovery and drug development. Alternative splicing of the cytochrome CYP gene transcripts enhances gene diversity and may play a role in transcriptional regulation of certain CYP proteins. Tissue-specific alternative splicing of CYPs is significant for its potential to add greater dimension to differential drug metabolism in hepatic and extrahepatic tissues, such as the brain, and to our understanding of the CYP family. This review provides an overview of tissue-specific splicing patterns, splicing types, regulation and the functional diversities between liver and splice variant CYP proteins and further explores the relevance of tissue-specific alternative splicing of CYPs in the nervous system.

Alternative splicing within the human cytochrome P450 superfamily with an emphasis on the brain: The convolution continues. Publishing Authors By Initials

CM Turman,JM Hatley,DJ Ryder,V Ravindranath,HW Strobel,

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Alternative splicing within the human cytochrome P450 superfamily with an emphasis on the brain: The convolution continues. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert opinion on drug metabolism & toxicology

VOLUME: 2

Page Numbers: 399-418

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ISSN: 1742-5255

DAY: 3

MONTH: Jun

YEAR: 2006

Alternative splicing within the human cytochrome P450 superfamily with an emphasis on the brain: The convolution continues. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Alternative splicing within the human cytochrome P450 superfamily with an emphasis on the brain: The convolution continues.

AFFILIATION: Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, 6431 Fannin, Houston, TX 77030, USA. cheri.m.turman@uth.tmc.edu

Country: England

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MEDLINETA: Expert Opin Drug Metab Toxicol

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