Alternative splicing: therapeutic target and tool.

Alternative splicing: therapeutic target and tool. Research Abstract Details 

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Alternative splicing: therapeutic target and tool. Abstract Text:

Mariano A Garcia-Blanco,

Alternative splicing swells the coding capacity of the human genome, expanding the pharmacoproteome, the proteome that provides targets for therapy. Splicing, both constitutive and regulated forms, can itself be targeted by conventional and molecular therapies. This review focuses on splicing as a therapeutic target with a particular emphasis on molecular approaches. The review looks at the use of antisense oligonucleotides, which can be employed to promote skipping of constitutive exons, inhibit inappropriately activated exons, or stimulate exons weakened by mutations. Additionally this manuscript evaluates methods that reprogram RNAs using reactions that recombine RNA molecules in trans. Preliminary, but exciting, results in these areas of investigation suggest that these methods could eventually lead to treatments in heretofore intractable ailments.

Alternative splicing: therapeutic target and tool. Publishing Authors By Initials

MA Garcia-Blanco,

For similar therapeutics research abstracts see: therapeutics research

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Alternative splicing: therapeutic target and tool. Journal Published:

PUBLICATION TYPE: Review

Journal: Progress in molecular and subcellular biology

VOLUME: 44

Page Numbers: 47-64

Journal Abbreviation: Prog. Mol. Subcell. Biol.

ISSN: 0079-6484

DAY: 3

MONTH: 12

YEAR: 2006

Alternative splicing: therapeutic target and tool. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 233223

Alternative splicing: therapeutic target and tool. Keywords Mesh Terms:

KEYWORDS: Therapeutics

MESH TERMS: methods

Chemical & Substance for Abstract: Alternative splicing: therapeutic target and tool. Information

Substance Name: RNA Precursors

Registry Number: 0

Grant and Affiliation Information for Alternative splicing: therapeutic target and tool.

AFFILIATION: Department of Molecular Genetics and Microbiology, Center for RNA Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM63090

ACRONYM: GM

MEDLINETA: Prog Mol Subcell Biol

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