Alternaria measures in inner-city, low-income housing by immunoassay and culture-based analysis.

Alternaria measures in inner-city, low-income housing by immunoassay and culture-based analysis. Research Abstract Details 

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Alternaria measures in inner-city, low-income housing by immunoassay and culture-based analysis. Abstract Text:

BACKGROUND: Sensitivity to Alternaria allergens has been associated with severe asthma and life-threatening exacerbations, and a high prevalence of Alternaria sensitivity has been reported among inner-city populations. Traditionally, epidemiologic studies have measured indoor Alternaria concentrations by cultural analyses; however, the number of viable spores may not be a good proxy for allergen levels. Furthermore, other genera share epitopes with Alternaria that may contribute to the allergenic effect. OBJECTIVE: To compare measures of Alternaria antigen by enzyme-linked immunosorbent assay with measures of Alternaria and cross-reactive genera (Ulocladium, Curvularia, Epicoccum, and Stemphylium) by cultural analysis. METHOD: Antigen assays and cultural analyses were performed on vacuum-collected bed dust samples collected between June 18, 2002, and February 9, 2004, from 3 inner-city, low-income public housing developments. RESULTS: Alternaria antigen was found in all bed dust samples regardless of season. However, culturable Alternaria, Ulocladium, Curvularia, Epicoccum, and Stemphylium were only found in 50%, 35%, 6%, 11%, and 0% of bed samples, respectively. No correlations were found between Alternaria antigen and culturable concentrations of Alternaria or of its cross-reactive genera except for marginal correlation with Ulocladium culturable concentrations. CONCLUSIONS: The results confirm that exposure to Alternaria antigens and allergens can occur even in the absence of culturable Alternaria or its cross-reactive genera, so further refinement and use of assays are essential for characterizing the distribution and determinants of indoor fungal allergen levels forsensitive populations.

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Alternaria measures in inner-city, low-income housing by immunoassay and culture-based analysis. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Annals of allergy, asthma & immunology : official

VOLUME: 100

Page Numbers: 364-9

Journal Abbreviation: Ann. Allergy Asthma Immunol.

ISSN: 1081-1206

DAY: 2

MONTH: Apr

YEAR: 2008

Alternaria measures in inner-city, low-income housing by immunoassay and culture-based analysis. Information

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LANGUAGE: eng

NlmUniqueID: 9503580

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Grant and Affiliation Information for Alternaria measures in inner-city, low-income housing by immunoassay and culture-based analysis.

AFFILIATION: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA. jpeters@hsph.harvard.edu

Country: United States

AGENCY: United States NIEHS

GRANT: P30 ES00002

ACRONYM: ES

MEDLINETA: Ann Allergy Asthma Immunol

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