Altered macroautophagy in the spinal cord of SOD1 mutant mice.

Altered macroautophagy in the spinal cord of SOD1 mutant mice. Research Abstract Details 

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Altered macroautophagy in the spinal cord of SOD1 mutant mice. Abstract Text:

Liang Li,Xiaojie Zhang,Weidong Le,

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by selective loss of motor neurons (MNs). About 20% familial cases of ALS (fALS) carried the Cu, Zn-superoxide dismutase (SOD1) gene mutation, which plays a crucial role in the pathogenesis of fALS. There is evidence suggesting that macroautophagy can degrade mutated SOD1 in vitro. To investigate whether the mutant SOD1 can induce macroautophagy in vivo, we examined the LC3 processing in spinal cord and the activation status of macroautophagy in MNs of SOD1(G93A) transgenic mice at different stages. Our data demonstrated that autophagy was activated in spinal cord of SOD1(G93A) mice indicating a possible role of macroautophagy in the pathogenesis of ALS.

Altered macroautophagy in the spinal cord of SOD1 mutant mice. Publishing Authors By Initials

L Li,X Zhang,W Le,

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Altered macroautophagy in the spinal cord of SOD1 mutant mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Autophagy

VOLUME: 4

Page Numbers: 290-3

Journal Abbreviation: Autophagy

ISSN: 1554-8635

DAY: 7

MONTH: 01

YEAR: 2008

Altered macroautophagy in the spinal cord of SOD1 mutant mice. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Altered macroautophagy in the spinal cord of SOD1 mutant mice.

AFFILIATION: Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine & Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China.

Country: United States

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MEDLINETA: Autophagy

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