Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus.

Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus. Research Abstract Details 

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Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus. Abstract Text:

Stella A Nicolaou,Peter Szigligeti,Lisa Neumeier,Susan Molleran Lee,Heather J Duncan,Shashi K Kant,Anne Barbara Mongey,Alexandra H Filipovich,Laura Conforti,

Aberrant T cell responses during T cell activation and immunological synapse (IS) formation have been described in systemic lupus erythematosus (SLE). Kv1.3 potassium channels are expressed in T cells where they compartmentalize at the IS and play a key role in T cell activation by modulating Ca(2+) influx. Although Kv1.3 channels have such an important role in T cell function, their potential involvement in the etiology and progression of SLE remains unknown. This study compares the K channel phenotype and the dynamics of Kv1.3 compartmentalization in the IS of normal and SLE human T cells. IS formation was induced by 1-30 min exposure to either anti-CD3/CD28 Ab-coated beads or EBV-infected B cells. We found that although the level of Kv1.3 channel expression and their activity in SLE T cells is similar to normal resting T cells, the kinetics of Kv1.3 compartmentalization in the IS are markedly different. In healthy resting T cells, Kv1.3 channels are progressively recruited and maintained in the IS for at least 30 min from synapse formation. In contrast, SLE, but not rheumatoid arthritis, T cells show faster kinetics with maximum Kv1.3 recruitment at 1 min and movement out of the IS by 15 min after activation. These kinetics resemble preactivated healthy T cells, but the K channel phenotype of SLE T cells is identical to resting T cells, where Kv1.3 constitutes the dominant K conductance. The defective temporal and spatial Kv1.3 distribution that we observed may contribute to the abnormal functions of SLE T cells.

Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus. Publishing Authors By Initials

SA Nicolaou,P Szigligeti,L Neumeier,SM Lee,HJ Duncan,SK Kant,AB Mongey,AH Filipovich,L Conforti,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research

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Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 346-56

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Jul

YEAR: 2007

Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus. Keywords Mesh Terms:

KEYWORDS: T-Lymphocyte Subsets

MESH TERMS: pathology

Chemical & Substance for Abstract: Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus. Information

Substance Name: Receptors, Antigen, T-Cell

Registry Number: 0

Grant and Affiliation Information for Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus.

AFFILIATION: Department of Internal Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA 95286

ACRONYM: CA

MEDLINETA: J Immunol

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