Altered default mode network activity in patient with anxiety disorders: an fMRI study.

Altered default mode network activity in patient with anxiety disorders: an fMRI study. Research Abstract Details 

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Altered default mode network activity in patient with anxiety disorders: an fMRI study. Abstract Text:

Xiao-Hu Zhao,Pei-Jun Wang,Chun-Bo Li,Zheng-Hui Hu,Qian Xi,Wen-Yuan Wu,Xiao-Wei Tang,Xiao-Hu Zhao,Pei-Jun Wang,Chun-Bo Li,Zheng-Hui Hu,Qian Xi,Wen-Yuan Wu,Xiao-Wei Tang,

Anxiety disorder, a common mental disorder in our clinical practice, is characterized by unprovoked anxiety. Medial prefrontal cortex (MPFC) and posterior cingulate cortex (PCC), which closely involved in emotional processing, are critical regions in the default mode network. We used functional magnetic resonance imaging (fMRI) to investigate whether default mode network activity is altered in patients with anxiety disorder. Ten anxiety patients and 10 healthy controls underwent fMRI while listening to emotionally neutral words alternating with rest (Experiment 1) and threat-related words alternating with emotionally neutral words (Experiment 2). In Experiment 1, regions of deactivation were observed in patients and controls. In Experiment 2, regions of deactivation were observed only in patients. The observed deactivation patterns in the two experiments, which included MPFC, PCC, and inferior parietal cortex, were similar and consistent with the default model network. Less deactivation in MPFC and greater deactivation in PCC were observed for patients group comparing to controls in Experiment 1. Our observations suggest that the default model network is altered in anxiety patients and dysfunction in MPFC and PCC may play an important role in anxiety psychopathology.

Altered default mode network activity in patient with anxiety disorders: an fMRI study. Publishing Authors By Initials

XH Zhao,PJ Wang,CB Li,ZH Hu,Q Xi,WY Wu,XW Tang,XH Zhao,PJ Wang,CB Li,ZH Hu,Q Xi,WY Wu,XW Tang,

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Altered default mode network activity in patient with anxiety disorders: an fMRI study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of radiology

VOLUME: 63

Page Numbers: 373-8

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ISSN: 0720-048X

DAY: 2

MONTH: 04

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Altered default mode network activity in patient with anxiety disorders: an fMRI study.

AFFILIATION: Imaging Department of Tong Ji Hospital of Tong Ji University, Shanghai 200065, PR China. xhzhao999@263.net

Country: Ireland

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MEDLINETA: Eur J Radiol

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