Alterations of hemostasis after laparoscopic and open surgery.

Alterations of hemostasis after laparoscopic and open surgery. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Alterations of hemostasis after laparoscopic and open surgery. Abstract Text:

Background: After tissue injury caused by trauma or surgery, alterations of hemostasis are observed and there is a risk for postoperative thromboembolic complications. Laparoscopic surgery, by causing limited tissue injury, appears to be associated with a lower risk for thromboembolism than open surgery. We conducted a prospective randomized study in order to detect potentially existing differences in activation of coagulation and fibrinolytic pathways between open and laparoscopic surgery. Methods: Forty patients suffering from chronic cholelithiasis were randomly assigned to undergo open (group A n = 20) or laparoscopic cholecystectomy (group B n = 20) by the same surgical and anesthesiology team. Demographic data were comparable. Blood samples were taken (a) preoperatively, (b) at the end of the procedure, (c) 24 h postoperatively and (d) 72 h postoperatively. The following parameters were measured and compared within each group and between groups: platelets (PLT), soluble fibrin monomer complexes (SFMC), fibrin degradation products (FDP), D-dimers (D-D), fibrinogen (FIB), activated partial thromboplastin time (APTT), prothrombin time (PT). Thrombin-antithrombin III complexes (TAT) were measured at 24 and 72 h postoperatively. Prothrombin fragment 1 + 2 (F1 + 2) was measured at 24 and 72 h postoperatively in 11 patients of group A and 13 patients of group B, respectively. Results: Demographics were comparable between groups. Immediately postoperatively, TAT and F1 + 2 were significantly higher in group A as compared to group B (p < 0.05). They also increased significantly postoperatively as compared to preoperative levels within each group (p < 0.05). D-dimers were significantly higher in group A as compared to group B (p < 0.01) immediately postoperatively. D-dimers also increased significantly postoperatively in group B as compared to preoperative levels (p < 0.001). FIB decreased slightly in both groups at 24 h postoperatively but there was a significant increase in group A as compared to group B (p < 0.01). SFMC were detected twice in group A and only once group B. FDP levels over 5 mug/ml were detected more often in group A than in group B (p < 0.05). No patient from either group suffered thromboembolism or abnormal bleeding as a postoperative complication. Conclusions: Open surgery as compared to laparoscopic procedures leads to activation of the clotting system of a higher degree. Although of a lower degree, hypercoagulability is still observed in patients undergoing laparoscopic surgery and, therefore, routine thromboembolic prophylaxis should be considered.

Alterations of hemostasis after laparoscopic and open surgery. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Alterations of hemostasis after laparoscopic and open surgery. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hematology (Amsterdam, Netherlands)

VOLUME: 12

Page Numbers: 561-70

Journal Abbreviation: Hematology

ISSN: 1607-8454

DAY: 15

MONTH: Dec

YEAR: 2007

Alterations of hemostasis after laparoscopic and open surgery. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9708388

Alterations of hemostasis after laparoscopic and open surgery. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Alterations of hemostasis after laparoscopic and open surgery. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Alterations of hemostasis after laparoscopic and open surgery.

AFFILIATION: 1st Department of Surgery, Athens Medical School, "Laiko" University Hospital, Athens, Greece.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Hematology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Alterations of hemostasis after laparoscopic and open surgery Related Publications

• A hybrid approach using a composite endovascular and open graft procedure for a symptomatic common femoral aneurysm extending well above the inguinal ligament.
• Alterations of hemostasis after laparoscopic and open surgery.
• Can the diameter of endoluminal shunt influence the risk of hyperperfusion syndrome after carotid endarterectomy?
• Comparison of safety and efficacy of ultrasonic and bipolar thermal energy: an experimental study.
• Emergency stenting of a ruptured infected anastomotic femoral pseudoaneurysm.
• Endovascular repair of a type III thoracoabdominal aortic aneurysm in a patient with occlusion of visceral arteries.
• Epstein-Barr virus - associated adenocarcinoma of the stomach: a rare entity with distinct characteristics.
• High-Sensitivity CRP Is Correlated With Neurologic Symptoms and Plaque Instability in Patients With Severe Stenosis of the Carotid Bifurcation.
• Primary stenting for aortic lesions: From single stenoses to total aortoiliac occlusions.
• The relationship of endothelin-1 and inducible nitric oxide synthase at several stages of the anastomotic healing process.
• The use of Speckle Reduction Imaging (SRI) Ultrasound in the characterization of carotid artery plaques.