Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism.

Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism. Abstract Text:

Kiyoko Hosaka,Junichiro James Kazama,Suguru Yamamoto,Yumi Ito,Noriaki Iino,Hiroki Maruyama,Akihiko Saito,Ichiei Narita,Fumitake Gejyo,

Calcitriol therapy is a central strategy for the treatment of uremic secondary hyperparathyroidism. Although indiscriminate use of calcitriol may lead to worse outcomes, it is difficult to make a decision to discontinue calcitriol therapy when its parathyroid suppression effect remains unsatisfactory. In this study, intravenous calcitriol was administered to 120 chronic hemodialysis patients. Therapy continued for 48 weeks or until plasma intact parathyroid hormone (iPTH) levels decreased to below 300 pg/ml or until the development of any significant adverse effect. Of the 120 patients, the treatment goal was achieved in 47 patients during the first 4 weeks, in 10 during the next 4 weeks, and in 22 patients thereafter. Logistic regression analysis and stepwise regression analysis revealed that iPTH levels were the only significant predictor of the response to calcitriol therapy at weeks 0 and 4. Besides iPTH, the inorganic phosphate (P) levels were another significant predictor of the ultimate response to calcitriol therapy at week 8. The point of best discrimination for successful treatment was P = 6.0 mg/dl at week 8, or P level at week 8/pretreatment P level = 1.0. In conclusion, the P level at week 8 is a predictor of the response to calcitriol therapy for uremic secondary hyperparathyroidism. Changes in treatment are recommended if patients show unsatisfactory parathyroid suppression with a hyperphosphatemic tendency.

Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism. Publishing Authors By Initials

K Hosaka,JJ Kazama,S Yamamoto,Y Ito,N Iino,H Maruyama,A Saito,I Narita,F Gejyo,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of bone and mineral metabolism

VOLUME: 26

Page Numbers: 185-90

Journal Abbreviation: J. Bone Miner. Metab.

ISSN: 0914-8779

DAY: 27

MONTH: 02

YEAR: 2008

Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9436705

Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism.

AFFILIATION: Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-751 Asahimachi-dori, Niigata, Niigata, 951-8510, Japan.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Bone Miner Metab

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism Related Publications

• A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab.
• A case of Takayasu arteritis complicated with glomerulonephropathy mimicking membranoproliferative glomerulonephritis: a case report and review of the literature.
• A clinicopathological study on the long-term efficacy of tonsillectomy in patients with IgA nephropathy.
• Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism.
• An outbreak and isolation of drug-resistant Pseudomonas aeruginosa at Niigata University Hospital, Japan.
• Appropriate timing of CD40 ligation for RNA-Pulsed DCs to induce antitumor immunity.
• Atherosclerosis is accelerated in patients with long-term well-controlled Systemic Lupus Erythematosus (SLE).
• Naked Plasmid DNA-Based alpha-Galactosidase A Gene Transfer Partially Reduces Systemic Accumulation of Globotriaosylceramide in Fabry Mice.
• New advances in renal amyloidosis.
• Novel mutations of the GLA gene in Japanese patients with Fabry disease and their functional characterization by active site specific chaperone.
• Pathogenetic significance of aberrant glycosylation of IgA1 in IgA nephropathy.
• Pulmonary artery involvement in Takayasu's arteritis with lung infarction and pulmonary aspergillosis.
• Rapid detection of causative pathogen of peritonitis using in-situ hybridization in a patient with continuous ambulatory peritoneal dialysis.
• Role of megalin, a proximal tubular endocytic receptor, in calcium and phosphate homeostasis.
• Serum cystatin C measured by a sol particle homogeneous immunoassay can accurately detect early impairment of renal function.
• Sustained transgene expression in rat kidney with naked plasmid DNA and PCR-amplified DNA fragments.
• The patient health questionnaire, Japanese version: validity according to the mini-international neuropsychiatric interview-plus.
• Two-dimensional analysis of elements and mononuclear cells in hard metal lung disease.
• Uremic pruritus in chronic hemodialysis patients.
• [Chronic eosinophilic pneumonia complicated by bronchial asthma and diabetes mellitus successfully treated with suplatast tosilate and high-dose inhaled corticosteroid therapy]
• [Combination of Cisplatin and vinorelbine as adjuvant chemotherapy in non-small cell lung cancer patients - feasibility assessment of 5 consecutively treated patients.]