Alterations in retrograde axonal transport in optic nerve of type I and type II diabetic rats.

Alterations in retrograde axonal transport in optic nerve of type I and type II diabetic rats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Alterations in retrograde axonal transport in optic nerve of type I and type II diabetic rats. Abstract Text:

Clinical and electrophysiological examinations have yielded visual pathway function abnormalities in both humans and animal models with diabetes mellitus (DM). However, subclinical involvement of the optic nerve has not yet been fully investigated. In this study, we demonstrated the different impairments in retrograde axonal transport occurring in selective retinal ganglion cells (RGCs) of Type I and II diabetic rats. Rats were injected with streptozotocin (STZ) to induce Type I DM. The Otsuka Long-Evans Tokushima Fatty (OLETF) rats represented the Type II DM group. The STZ-induced (Type I) diabetic rats had low body weights and significant elevations in blood glucose levels compared with the age-matched control rats. On the contrary, the OLETF rats (Type II) had high body weights and significant elevations in blood glucose concentrations compared with the age-matched controls. Fluoro-Gold (FG) was injected into the bilateral dorsal lateral geniculate nucleus. Accumulation of FG in large and medium type RGCs in STZ-induced diabetic rats was significantly decreased compared with the controls. However, the accumulation of FG in RGCs of OLETF rats did not show a significant decrease compared with the controls. Our findings suggest that, within the time frame of study, retrograde axonal transport impairment of large and medium type RGCs in the STZ-induced (Type I DM) diabetic rats was greater than in the OLETF (Type II DM) diabetic rats. Impairment of retrograde axonal transport in Type I diabetes may precede or be a consequence of metabolic dysfunctions in the large and medium-sized RGCs eventually leading to optic nerve atrophy.

Alterations in retrograde axonal transport in optic nerve of type I and type II diabetic rats. Publishing Authors By Initials

For similar organic chemicals: amidines: stilbamidines research abstracts see: organic chemicals: amidines: stilbamidines research

PUBMED ID PMID:

MEDLINE DATE:

Alterations in retrograde axonal transport in optic nerve of type I and type II diabetic rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Kobe journal of medical sciences

VOLUME: 44

Page Numbers: 205-15

Journal Abbreviation: Kobe J Med Sci

ISSN: 0023-2513

DAY: 8

MONTH: Dec

YEAR: 1998

Alterations in retrograde axonal transport in optic nerve of type I and type II diabetic rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413531

Alterations in retrograde axonal transport in optic nerve of type I and type II diabetic rats. Keywords Mesh Terms:

KEYWORDS: Stilbamidines

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Alterations in retrograde axonal transport in optic nerve of type I and type II diabetic rats. Information

Substance Name: Stilbamidines

Registry Number: 0

Grant and Affiliation Information for Alterations in retrograde axonal transport in optic nerve of type I and type II diabetic rats.

AFFILIATION: Department of Ophthalmology, Kobe University School of Medicine.

Country: JAPAN

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Kobe J Med Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Alterations in retrograde axonal transport in optic nerve of type I and type II diabetic rats Related Publications

• CO2-enhanced sonographically guided radiofrequency ablation and transcatheter arterial chemoembolization for small hepatocellular carcinoma poorly defined on conventional sonography.
• Contested dominance modifies the anovulatory consequences of social subordination in female marmosets.
• Decreased fractal correlation in diurnal physical activity in chronic fatigue syndrome.
• Descriptive study of gallbladder, extrahepatic bile duct, and ampullary cancers in the United States, 1997-2002.
• Diastereo- and enantioselective synthesis of nitroso Diels-Alder-type bicycloketones using dienamine: mechanistic insight into sequential nitroso Aldol/Michael reaction and application for optically pure 1-amino-3,4-diol synthesis.
• Drosophila CTLA-2-like protein (D/CTLA-2) inhibits cysteine proteinase 1 (CP1), a cathepsin L-like enzyme.
• Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release.
• Effects of bilateral jugular vein ligation on local cerebral blood flow.
• Effects of brain lesions on taste-potentiated odor aversion in rats.
• Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function.
• Evaluation of osteogenic/chondrogenic cellular proliferation and differentiation in the xenogeneic periosteal graft.
• Gene expression signatures that can discriminate oral leukoplakia subtypes and squamous cell carcinoma.
• Haloperidol treatment after high-dose methamphetamine administration is excitotoxic to GABA cells in the substantia nigra pars reticulata.
• Imaging of Regional Differences of Muscle Oxygenation during Exercise Using Spatially Resolved NIRS.
• Interactions between methamphetamine and environmental stress: role of oxidative stress, glutamate and mitochondrial dysfunction.
• Intraoperative electro-oculographic Monitoring for Skull Base Surgery.
• Involvement of the Mesolimbic System in Palatability-induced Ingestion.
• Ketamine and N-acetylaspartylglutamate peptidase inhibitor exert analgesia in bone cancer pain.
• Kinetic mechanism of the fastest motor protein, Chara myosin.
• Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.
• Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor kappaB activation.
• Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects.
• Negative regulation of BMP/Smad signaling by Tob in osteoblasts.
• Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor.
• Regulation of Wnt signalling by receptor-mediated endocytosis.
• Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression.
• The Role of Orexigenic Neuropeptides in the Ingestion of Sweet-tasting Substances in Rats.
• The relationship between cerebral blood flow and cognitive function in patients with brain insult of various etiology.
• The use of polylactic acid/polyglycolic acid copolymer and gelatin sponge complex containing human recombinant bone morphogenetic protein-2 following condylectomy in rabbits.
• Trehalose Sensitivity of the Gustatory Receptor Neurons Expressing Wild-type, Mutant and Ectopic Gr5a in Drosophila.