Alterations in immune functions during normal aging and Alzheimer's disease.

Alterations in immune functions during normal aging and Alzheimer's disease. Research Abstract Details 

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Alterations in immune functions during normal aging and Alzheimer's disease. Abstract Text:

It is thought that aging induces immune changes, which are related to the pathophysiology of Alzheimer's disease (DAT). In this study, the total number of leukocytes, white blood cell differentiation, mitogen-induced lymphocytic proliferation, neutrophil phagocytosis and superoxide release, and prostaglandin E2 (PGE2) production by mitogen-stimulated whole blood cultures were comparatively investigated between healthy adults (range 22-45 years) and healthy elderly volunteers (range 70-91 years), and between DAT patients (range 56-94 years) and age-matched control subjects. Healthy elderly volunteers showed significantly lower phytohemagglutinin (PHA)-induced lymphocyte proliferation and percentage and absolute number of basophils than young volunteers. In normal volunteers, there were significant and negative correlations between age and the number of basophils. Patients with DAT showed a trend toward significantly higher PHA-induced lymphocyte proliferation and significantly decreased percentage and absolute number of large unstained cells than healthy volunteers. In DAT patients, the total number of leukocytes and the percentage and number of neutrophils were positively correlated with age. All other immune-inflammatory variables were not significantly altered either by the aging process or DAT. The present study suggests that aging and DAT may differently affect some immune variables.

Alterations in immune functions during normal aging and Alzheimer's disease. Publishing Authors By Initials

For similar behavioral disciplines and activities: psychiatric status rating scales research abstracts see: behavioral disciplines and activities: psychiatric status rating scales research

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Alterations in immune functions during normal aging and Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Psychiatry research

VOLUME: 85

Page Numbers: 71-80

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 18

MONTH: Jan

YEAR: 1999

Alterations in immune functions during normal aging and Alzheimer's disease. Information

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LANGUAGE: eng

NlmUniqueID: 7911385

Alterations in immune functions during normal aging and Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: Psychiatric Status Rating Scales

MESH TERMS: immunology

Chemical & Substance for Abstract: Alterations in immune functions during normal aging and Alzheimer's disease. Information

Substance Name: Prostaglandins

Registry Number: 0

Grant and Affiliation Information for Alterations in immune functions during normal aging and Alzheimer's disease.

AFFILIATION: Clinical Research Centre for Mental Health, University Department of Psychiatry, AZ Stuivenberg, Antwerp, Belgium.

Country: IRELAND

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MEDLINETA: Psychiatry Res

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