Alterations in GABA(A) receptor alpha2 subunit mRNA expression following reproductive experience in rats.

Alterations in GABA(A) receptor alpha2 subunit mRNA expression following reproductive experience in rats. Research Abstract Details 

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Alterations in GABA(A) receptor alpha2 subunit mRNA expression following reproductive experience in rats. Abstract Text:

Elizabeth M Byrnes,Jong O Lee,Robert S Bridges,

BACKGROUND/AIM: Reproductive experience (i.e., pregnancy and lactation) alters anxiety-like behavior. One neurotransmitter system that may mediate the effects of reproductive experience on anxiety-like behavior is gamma-aminobutyric acid (GABA). The purpose of the current study was to determine whether reproductive experience alters the mRNA expression of selective GABA(A) receptor subunits in brain regions associated with anxiety-like behaviors. METHODS: Brains were collected from age-matched nulliparous and primiparous female rats in either diestrus or proestrus, and the subunit mRNA expression was determined using real-time reverse transcription-polymerase chain reaction with Taqman. RESULTS: Increased alpha1 mRNA expression was found in proestrus within both medial preoptic area (MPOA) and medial amygdala (MeA) in nulliparous and primiparous females. The expression of alpha2 mRNA was also increased within the MPOA in proestrus in both nulliparous and primiparous females; however, within the MeA, an increased alpha2 mRNA expression in proestrus was only observed in nulliparous females, with primiparous females having a significantly reduced expression when compared to nulliparous controls. In addition, a significant increase in the expression of alpha2 mRNA expression was observed within the periaqueductal gray of reproductively experienced female rats. CONCLUSION: These results indicate that reproductive experience results in significant shifts in the expression of GABA(A) alpha2 mRNA expression in the MeA.

Alterations in GABA(A) receptor alpha2 subunit mRNA expression following reproductive experience in rats. Publishing Authors By Initials

EM Byrnes,JO Lee,RS Bridges,

For similar reproductive and urinary physiology: reproduction research abstracts see: reproductive and urinary physiology: reproduction research

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Alterations in GABA(A) receptor alpha2 subunit mRNA expression following reproductive experience in rats. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuroendocrinology

VOLUME: 85

Page Numbers: 148-56

Journal Abbreviation: Neuroendocrinology

ISSN: 0028-3835

DAY: 7

MONTH: 05

YEAR: 2007

Alterations in GABA(A) receptor alpha2 subunit mRNA expression following reproductive experience in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 35665

Alterations in GABA(A) receptor alpha2 subunit mRNA expression following reproductive experience in rats. Keywords Mesh Terms:

KEYWORDS: Reproduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Alterations in GABA(A) receptor alpha2 subunit mRNA expression following reproductive experience in rats. Information

Substance Name: Receptors, GABA-A

Registry Number: 0

Grant and Affiliation Information for Alterations in GABA(A) receptor alpha2 subunit mRNA expression following reproductive experience in rats.

AFFILIATION: Department of Biomedical Sciences, Tufts University, Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA. elizabeth.byrnes@tufts.edu

Country: Switzerland

AGENCY: United States NICHD

GRANT: HD29895

ACRONYM: HD

MEDLINETA: Neuroendocrinology

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